Enhancement of antimicrobial activity of pump inhibitors associating drugs

Donatella Usai; Matthew Donadu; Alessandra Bua; Paola Molicotti; Stefania Zanetti; Sandra Piras; Paola Corona; Roberta Ibba; Antonio Carta

doi:10.3855/jidc.11102

Enhancement of antimicrobial activity of pump inhibitors associating drugs

Authors

Donatella Usai Department of Biological Science, University of Sassari, Sassari, Italy
Matthew Donadu Department of Biological Science, University of Sassari, Sassari, Italy https://orcid.org/0000-0001-7681-6194
Alessandra Bua Department of Biological Science, University of Sassari, Sassari, Italy
Paola Molicotti Department of Biological Science, University of Sassari, Sassari, Italy
Stefania Zanetti Department of Biological Science, University of Sassari, Sassari, Italy
Sandra Piras Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
Paola Corona Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
Roberta Ibba Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
Antonio Carta Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy

DOI:

https://doi.org/10.3855/jidc.11102

Keywords:

Bacteria, efflux, resistance

Abstract

Introduction: with the continuous emergence of pathogenic resistance to conventional drugs through efflux pumps, increasing efforts are directed toward discovering efflux inhibitory molecules.

Methodology: in this study three P-glycoprotein (P13CP, P22CP, P34CP) efflux-inhibitors (EIs), belonging to the series of phenoxymethylquinoxalines capable to restore/potentiate the antiproliferative activity of doxorubicin and vincristine against human tumor cell lines and different antibiotics against clinical isolates, were investigated on 10 clinical strains of Candida and 12 clinical and ATCC strains of Gram positive and Gram-negative bacteria.

Results: MFC values of FLC were reduced in all Candida strains by the P22CP and P34CP inhibitors, and in 5/10 fungal strains by the P13CP inhibitor.

Conclusion: novel antibiotics with new modes of action are urgently required to suppress the rise of MDR bacteria. An alternative approach would be to identify molecules that can interfere with the process of efflux.

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Published

2019-02-28

How to Cite

Usai D, Donadu M, Bua A, Molicotti P, Zanetti S, Piras S, Corona P, Ibba R, Carta A (2019) Enhancement of antimicrobial activity of pump inhibitors associating drugs. J Infect Dev Ctries 13:162–164. doi: 10.3855/jidc.11102

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Issue

Vol. 13 No. 02: February 2019

Section

Brief Original Articles

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