Trypanosoma cruzi infection in the human population of the Bolivian Chaco: four serosurveys over a 26-year period (1987-2013)

  • Michele Spinicci Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
  • Simona Gabrielli Dipartimento di Sanità Pubblica e Malattie Infettive, Università di Roma Sapienza, Rome, Italy
  • David Rojo Escuela de Salud del Chaco Tekove Katu, Gutierrez, Plurinational State of Bolivia
  • Herlan Gamboa Facultad Integral del Chaco, Universidad Autónoma Gabriel René Moreno, Camiri, Plurinational State of Bolivia
  • Fabio Macchioni Dipartimento di Scienze Veterinarie, Università degli Studi di Pisa, Pisa, Italy
  • Antonia Mantella Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
  • Yunni Lara Hospital S. Antonio de Los Sauces, Monteagudo, Plurinational State of Bolivia
  • Ana Liz Villagrán Hospital Básico de Villa Montes, Villa Montes, Plurinational State of Bolivia
  • Mimmo Roselli Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
  • Marianne Strohmeyer Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
  • Claudia Cinelli Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
  • Giampaolo Corti Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
  • Filippo Bartalesi SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
  • Roberto Vargas Santa Cruz Chagas Disease Control Program, Ministry of Health, Plurinational State of Bolivia
  • Adolfo Vedia Chuquisaca Chagas Disease Control Program, Ministry of Health, Plurinational State of Bolivia
  • Paul Castellanos Servicio Departamental de Salud de Tarija, Tarija, Plurinational State of Bolivia
  • Joaquín Monasterio Servicio Departamental de Salud de Santa Cruz, Santa Cruz, Plurinational State of Bolivia
  • Gabriella Cancrini Dipartimento di Sanità Pubblica e Malattie Infettive, Università di Roma Sapienza, Rome, Italy
  • Alessandro Bartoloni Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy
Keywords: Chagas disease, seroprevalence, Trypanosoma cruzi, Bolivia, Chaco

Abstract

Introduction: Chagas disease (CD) remains a public health concern in several Latin American countries. At global level, Bolivia has the highest CD burden and the Chaco region, in the southeast of the country, is the most affected area. We report the results of four serosurveys for Trypanosoma cruzi antibodies, carried out approximately ten years apart from each other, during the lapse 1987-2013, in different localities of the Bolivian Chaco.

Methodology: Four cross-sectional surveys were conducted in various localities, mostly rural, of the Bolivian Chaco, during the period 1987-2013.

Results: Although a reliable analysis of CD epidemiological trend is challenging, a partial reduction of anti-T. cruzi seroprevalence over the past four decades in the Bolivian Chaco may be assumed. In particular, in 1987 the exposure to T. cruzi in rural setting was universal since the first years of life, while it resulted gradually lower and age-dependent thereafter. Moreover, T. cruzi seroprevalence among women of reproductive age (15-45 years) has been persistently high in rural areas.

Conclusions: T. cruzi transmission is still active and CD remains a concern throughout the Bolivian Chaco. More efforts are needed in order to achieve a sustainable interruption of vector-borne CD transmission in this area.

Published
2020-02-29
How to Cite
1.
Spinicci M, Gabrielli S, Rojo D, Gamboa H, Macchioni F, Mantella A, Lara Y, Villagrán AL, Roselli M, Strohmeyer M, Cinelli C, Corti G, Bartalesi F, Vargas R, Vedia A, Castellanos P, Monasterio J, Cancrini G, Bartoloni A (2020) Trypanosoma cruzi infection in the human population of the Bolivian Chaco: four serosurveys over a 26-year period (1987-2013). J Infect Dev Ctries 14:199-206. doi: 10.3855/jidc.11127
Section
Original Articles