A cross-sectional study of real life data of HCV from Turkey south region

Keywords: hepatitis C virus, genotype, injection drug use, direct-acting antiviral

Abstract

Introduction: This study investigated demographic characteristics and the prevalence of viremia among anti-HCV-positive patients.

Methodology: Hospital records of adult patients with anti-HCV positivity between June 2016 and October 2018 were screened retrospectively. Demographic characteristics, genotype distribution, history of injection drug use (IDU), treatment data of HCV RNA-positive patients were investigated.

Results: The rate of anti-HCV seropositivity was 1.7% and 54.5% of these were viremic. 69.5% of the 869 viremic patients were male. The mean age was 62 ± 15 (18–95) years for women and 42 ± 19 (18-90) years for men (p < 0.0001). 42.7% of these patients had IDU history. Regarding age, patients with IDU history accounted for 95% of the 18–29 age group. The most common genotype in patients younger than 40 was genotype 3, and genotype 1b in those older than 40. Only 52% of viremic patients had received DAA therapy. Also, 62.2% of patients aged < 40 and 36% of patients > 40 did not receive treatment (p < 0.0001). The SVR12 rate in patients receiving DAA treatment and follow-up was 100%; SVR24 was 99.5%.

Conclusions: A shift in the demographic structure of HCV-infected patients due to the changing trends of the HCV transmission mode was observed in this study. On the other hand, the proportion of patients who received DAA therapy was low. A substantial proportion of untreated patients were young with a history of IDU. This indicates that without strategies targeting the patients, the patient load due to HCV-related cirrhosis and hepatocellular carcinoma may persist in the future.

Published
2020-04-30
How to Cite
1.
Suntur BM, Kaya H, Eker HB Şahin, Kara B, Bozok T, Unal N (2020) A cross-sectional study of real life data of HCV from Turkey south region. J Infect Dev Ctries 14:380-386. doi: 10.3855/jidc.11983
Section
Original Articles