Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania

  • Rashid Madebe Kilimanjaro Christian Medical University College, Moshi, Tanzania
  • Ireen Kiwelu Kilimanjaro Christian Medical University College, Moshi, Tanzania
  • Arnold Ndaro Kilimanjaro Christian Medical Centre, Moshi, Tanzania
  • Filbert Francis National Institute for Medical Research, Tanga Centre, Tanzania
  • Vito Baraka National Institute for Medical Research, Tanga Centre, Tanzania https://orcid.org/0000-0001-9694-9293
  • Zahra Theilgaard Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  • Terese Katzenstein Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Keywords: Herpes simplex virus type 2, human immunodeficiency virus, adolescents, youth, Tanzania

Abstract

Introduction: Herpes Simplex virus type 2 (HSV-2) infection is associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) acquisition and transmission. Individuals co-infected with HIV-1 and HSV-2 may have longer lasting, more frequent and severe outbreaks of herpes symptoms. Previous studies have assessed HSV-2 seroprevalence and associated risk factors in adult populations. However, there is limited data on the HSV-2 seroprevalence among adolescents and youth living with HIV-1. The study aimed to determine the HSV-2 seroprevalence and associated risk factors among adolescents and youth living with HIV-1 at referral hospital setting in Northern Tanzania.

Methodology: A cross-sectional survey was conducted between February and July 2017 among HIV-1-infected individuals aged 10-24 years attending the Child -Centred Family Care Clinic at Kilimanjaro Christian Medical Centre. Blood specimens from 180 individuals were collected for ELISA-based detection of HSV-2 antibodies. Associations between risk factors and HSV-2 seroprevalence were analysed by univariate and multivariate logistic regression models.

Results: The overall HSV-2 seroprevalence was 18% (32/180). A significant HSV-2 seroprevalence was noted among adolescents and youth, who reported having had sexual intercourse than those who never had sexual intercourse (28.9% vs 13.3%, p = 0.02). Youths aged 20-24 had six folds higher risk of HSV-2 seroprevalence compared to those aged 10-14 years (AOR = 5.97 95% CI 1.31 – 27.19, p = 0.02).

Conclusions: Our study found that HSV-2 seroprevalence increased by age among adolescents and youth living with HIV-1. Age-specific approaches might play an important role in interventions targeting HSV-2 infection.

Published
2020-04-30
How to Cite
1.
Madebe R, Kiwelu I, Ndaro A, Francis F, Baraka V, Theilgaard Z, Katzenstein T (2020) Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania. J Infect Dev Ctries 14:398-403. doi: 10.3855/jidc.11599
Section
Brief Original Articles