KPC-2 producing Pseudomonas putida as an unexpected pathogen of catheter-associated bloodstream infection

Authors

  • Raiane Cardoso Chamon Pathology Department, Medical School of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
  • Jaqueline Abel da Rocha Comissão de Controle de Infecção Hospitalar, Hospital Universitário Antonio Pedro, Medical School of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
  • Isabella Araujo Martins Comissão de Controle de Infecção Hospitalar, Hospital Universitário Antonio Pedro, Medical School of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
  • Laís Lopes Pires Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
  • Breno Macêdo de Almeida Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
  • Nahara Souza Leite Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
  • Cláudia Rezende Vieira de Mendonça Souza Pathology Department, Medical School of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
  • Viviane Zahner Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
  • Rachel Leite Ribeiro Pathology Department, Medical School of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
  • Thiago Pavoni Gomes Chagas Pathology Department, Medical School of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
  • Ianick Souto Martins Infectious Diseases Section, Internal Medicine Departament, Medical school of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil

DOI:

https://doi.org/10.3855/jidc.12145

Keywords:

Pseudomonas putida, Bloodstream infection, Klebsiella pneumoniae carbapenemase, KPC

Abstract

Infections due to multidrug resistant Gram-negative pathogens are of great concern worldwide, as they are frequently associated with high mortality and morbidity rates. The occurrence of Pseudomonas spp. producing Klebsiella pneumoniae carbapenemases (KPCs) imposes a great challenge through treatment course of bloodstream infections (BSIs). Pseudomonas putida has been recognized as an emerging pathogen of healthcare associated infections (HAIs). Therefore, we aimed to report a case of a non-fatal case of peripheral line associated BSI (PLA-BSI) in an immunocompromised host due to P. putida harboring blaKPC-2 gene in Brazil. A P. putida isolate was recovered from a blood culture of a 72-year-old man admitted at a University Hospital, identified by BD Phoenix™ 100 (Becton, Dickinson and Company), causing PLA-BSI. The species identification was confirmed by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) and resistance to carbapenems were confirmed by Epsilometer test (E-test®). Additionally, the presence of important carbapenemases genes (blaKPC, blaNDM, blaOXA-48-like, blaSPM, blaIMP, blaVIM) was investigated by Polymerase Chain Reaction. The bacterial isolate was confirmed as meropenem resistant P. putida harboring blaKPC-2 gene.Thereofre, these fidings suggest that P. putida can work as a reservoir for resistance genes as this bacterium has the ability to disseminate through water-fluids inside hospital and community settings. Moreover, this paper highlights that a frequent and worldwide disseminated mechanism of resistance (blaKPC-2) is currently occurring among uncommon agents of BSI.

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Published

2020-04-30

How to Cite

1.
Chamon RC, Abel da Rocha J, Araujo Martins I, Lopes Pires L, Macêdo de Almeida B, Souza Leite N, Rezende Vieira de Mendonça Souza C, Zahner V, Leite Ribeiro R, Pavoni Gomes Chagas T, Souto Martins I (2020) KPC-2 producing Pseudomonas putida as an unexpected pathogen of catheter-associated bloodstream infection. J Infect Dev Ctries 14:411–414. doi: 10.3855/jidc.12145

Issue

Section

Case Reports