Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection

  • Ruzica Lukic Department of Microbiology, Faculty of Medicine Foča, University of East Sarajevo, Foča, Bosnia and Herzegovina
  • Maja Cupic Department of Microbiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Nevena Gajovic Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Milena Jurisevic Department of clinical pharmacy, Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia
  • Zeljko Mijailovic Department of infectious diseases, Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia
  • Bojana Davidovic Department of Dentistry, Faculty of Medicine, University of East Sarajevo, Foča, Bosnia and Herzegovina
  • Bojan Kujundzic Department of Dentistry, Faculty of Medicine, University of East Sarajevo, Foča, Bosnia and Herzegovina
  • Bojan Joksimovic Pediatric Department, Faculty of Medicine Foča, University of East Sarajevo, Foča, Bosnia and Herzegovina
  • Nebojsa Arsenijevic Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Ivan Jovanovic Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Keywords: HCV, end-stage renal disease, sST2

Abstract

Introduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and blood products, nosocomial transmission of HCV, and prolong hemodialysis duration. The aim of the study was to evaluate the influence of IL-33/ST2 signaling pathway on severity of the liver disease in ESRD HCV+ patients.

Methodology: Blood samples from patients with end stage renal disease (ESRD) and hepatitis C infection (HCV), 20 patients with HCV infection, 20 patients with ESRD and 20 healthy control donor patients were taken for the examination of biochemical parameters, for the determination of the serum cytokine concentration, and for the molecular diagnostics of HCV.

Results: Systemic sST2 positively correlated with serum level of urea and creatinine, respectively. Serum sST2 was significantly increased in ESRD HCV+ patients in comparison to HCV+ group. sST2/IL-1, sST2/IL-4 and sST2/IL-23 ratios were significantly increased in serum of ESRD HCV+ patients in comparison to HCV+ patients. Significantly higher systemic level of sST2 and sST2/IL-1 and sST2/IL-4 ratios were measured in ESRD patients compared to non-ESRD patients.

Conclusion: These results suggested that elevated level sST2, as the consequence of renal failure, causes less destruction of liver in HCV infection.

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Published
2020-05-31
How to Cite
1.
Lukic R, Cupic M, Gajovic N, Jurisevic M, Mijailovic Z, Davidovic B, Kujundzic B, Joksimovic B, Arsenijevic N, Jovanovic I (2020) Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection. J Infect Dev Ctries 14:519-526. doi: 10.3855/jidc.11741
Section
Original Articles