Improving the early diagnosis of suspected patients with COVID-19: a retrospective study of 106 patients

  • Xuesong Gao Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Di Yang Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Zheng Yuan Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Yijin Zhang Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Hongjie Li Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Ping Gao Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Xiaomin Liu Department of Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Wenshan Zhao Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Te Xiao Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Yanlin Guan Division of Disease Control, Beijing Ditan Hospital, Capital Medical University, Beijing, China
  • Guiju Gao
  • Xuefei Duan Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Keywords: COVID-19, SARS-CoV-2, differential diagnosis, epidemiology

Abstract

Introduction: An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. This study aimed to analyze the clinical and epidemiologic characteristics of patients with COVID-19 to better differentiate the suspected patients in Beijing, China.

Methodology: This was a retrospective, single-center study. Clinical and epidemiologic data were collected from suspected patients with COVID-19 admitted to Beijing Ditan Hospital from January 29 to February 21, 2020.

Results: One hundred and six patients (60 males and 46 females, median age 36 years) were enrolled. Thirty-six patients were ultimately laboratory confirmed. Fifty-three were excluded from the diagnosis of COVID-19. The remaining 17 patients were highly suspected, although their nucleic acid tests were repeatedly negative. The confirmed patients and highly suspected patients had a significantly higher proportion of epidemiologic history than the excluded patients (P < 0.001). There was no significant difference in clinical symptoms or the underlying diseases among the three groups. The confirmed patients had a higher frequency of lymphopenia and eosinopenia than the highly suspected and excluded patients. Chest computed tomography scans showed bilateral lung involvement, and ground-glass opacity was more likely observed in the confirmed patients.

Conclusion: The clinical features of the confirmed patients with COVID-19 were insufficient for early diagnosis of COVID-19. The epidemiologic history was of great significance in the early diagnosis of COVID-19. More sensitive diagnostic methods are needed to aid the differential diagnosis of suspected patients with COVID-19.

Published
2020-06-30
How to Cite
1.
Gao X, Yang D, Yuan Z, Zhang Y, Li H, Gao P, Liu X, Zhao W, Xiao T, Guan Y, Gao G, Duan X (2020) Improving the early diagnosis of suspected patients with COVID-19: a retrospective study of 106 patients. J Infect Dev Ctries 14:547-553. doi: 10.3855/jidc.12992
Section
Coronavirus Pandemic