Colonization by multidrug-resistant microorganisms of hospitalized newborns and their mothers in the neonatal unit context

  • Andressa Midori Sakai Departamento de Enfermagem, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Thayla Nadrielly Aparecida Nicolino Iensue Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Kauana Olanda Pereira Departamento de Enfermagem, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Nathália Aparecida Andrade de Souza Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Claudineia Maria Silva Laboratório de Microbiologia, Hospital Universitário, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Marta Silva de Almeida Salvador Departamento de Microbiologia, Laboratório de Ecologia Microbiana, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Renne Rodrigues Departamento de Saúde Coletiva, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Jaqueline Dario Capobiango Departamento de Pediatria e Cirurgia Pediátrica, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Marsileni Pelisson Departamento de Patologia, Análises Clínicas e Toxicológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Eliana Carolina Vespero Departamento de Patologia, Análises Clínicas e Toxicológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Lucy Megumi Yamauchi Lioni Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Marcia Regina Eches Perugini Departamento de Patologia, Análises Clínicas e Toxicológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Sueli Fumie Yamada Ogatta Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Edilaine Giovanini Rossetto Departamento de Enfermagem, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
  • Gilselena Kerbauy Departamento de Enfermagem, Universidade Estadual de Londrina, Londrina, Paraná, Brasil
Keywords: Premature, multiple antibacterial drug resistance, neonatal intensive care, mother-child relations

Abstract

Introduction: The mother plays a fundamental role in the constitution and regulation of her child's healthy microbiota, however, preterm newborns are separated from their mothers soon after birth and transferred to Neonatal Intensive Care Units, being exposed the constant risk for the development of multidrug-resistant microorganisms’ infections. The aim of this study was to explore the multidrug-resistant microorganism colonization of hospitalized babies and their mothers in the neonatal unit context.

Methodology: A prospective case study conducted with hospitalized babies and their mothers in the Neonatal Unit at a university hospital. The sample was composed of 433 binomials (mother-child). Colonization culture samples were taken at the moment of the baby’s discharge, via two swabs in the oral, nasal, axillary, inguinal, and rectal regions.

Results: The colonization incidence among the binomials, 30 (6.9%) were both colonized by multi-resistant microorganisms. Mothers of colonized babies (24.4%) demonstrated a higher chance of colonization in comparison to mothers of non-colonized babies (11.9%) (p = 0.002). Relationships were drawn between baby colonization and prematurity, extremely low birth weight, and non-exclusive maternal breastfeeding (p<0.05). ESBL-producing Gram-negative microorganisms were more frequent in the cultures of the binomials, with 35.9% of the babies colonized with Klebsiella spp. ESBL and 42.0% of the mothers with Escherichia coli ESBL. Furthermore, 50% of the binomials were colonized with E. coli ESBL.

Conclusion: The prematurity, extremely low birth weight, and non-exclusive breastfeeding at hospital discharge were associated with baby colonization by multidrug-resistant microorganism. Furthermore, mothers of colonized children presented higher chances of colonization.

Published
2020-07-31
How to Cite
1.
Sakai AM, Iensue TNAN, Pereira KO, de Souza NAA, Silva CM, Salvador MS de A, Rodrigues R, Capobiango JD, Pelisson M, Vespero EC, Lioni LMY, Perugini MRE, Ogatta SFY, Rossetto EG, Kerbauy G (2020) Colonization by multidrug-resistant microorganisms of hospitalized newborns and their mothers in the neonatal unit context. J Infect Dev Ctries 14:765-771. doi: 10.3855/jidc.12091
Section
Original Articles