Five-year period evaluation of isolated agents and their resistance profiles in intensive care unit patients with malignancy

  • Duygu Mert Infectious Diseases and Clinical Microbiology Clinic, University of Health Sciences Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
  • Selda Muslu Anesthesia and Reanimation Intensive Care Unit, University of Health Sciences Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
  • Alparslan Merdin Hematology Clinic and Bone Marrow Transplantation Unit, University of Health Sciences Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
  • Arif Timuroğlu Anesthesia and Reanimation Intensive Care Unit, University of Health Sciences Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
  • Ece Dirim Medical Microbiology Laboratory, University of Health Sciences Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
  • Süheyla Ünver Anesthesia and Reanimation Intensive Care Unit, University of Health Sciences Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
  • Mustafa Ertek Infectious Diseases and Clinical Microbiology Clinic, University of Health Sciences Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
Keywords: Gram-negative bacteria, Gram-positive bacteria, fungus, ICU

Abstract

Introduction: Patients treated in the intensive care unit (ICU) are usually patients who deteriorated health condition and could have longer hospital stay compared to other patients. Hospital infections are more common in ICU patients. The aim of this study was to evaluate the bacteria and treatment resistance profiles isolated from clinical specimens sent for hospital infections in ICU patients between January 1, 2014 and December 31, 2018.

Methodology: Bacteria isolated from various clinical samples sent for hospital infections in hospitalized patients in the Anesthesia and Reanimation Intensive Care Unit were retrospectively analyzed.

Results: Culture positivity was detected in 547 of the sent clinical samples. Eighty Gram-positive bacteria, 389 Gram-negative bacteria and 78 fungi infection were identified in a total of 547 positive cultures. In Gram-positive bacteria, 4 MRSA, 6 VRE and 30 MRCoNS were identified as resistant strains. In Gram-negative bacteria, Acinetobacter spp. was the most culture positive strain with the number of 223. Carbapenem resistance was found in 258 of the Gram-negative bacteria and ESBL positivity was found in 44 of the Gram-negative bacteria strains.

Conclusions: Gram-negative bacteria were the most frequently isolated strain in samples. Recently, colistin resistance has been increasing in Acinetobacter spp. and the increase in carbapenemase enzyme in Escherichia coli, Pseudomonas and Klebsiella species has increased resistance to carbapenems. Knowing the microorganisms that grow in ICUs and their antibiotic resistance patterns may help to prevent contamination of resistant microorganisms by both appropriate empirical antibiotic treatment and more isolation as well as general hygiene standard precautions.

Published
2020-08-31
How to Cite
1.
Mert D, Muslu S, Merdin A, Timuroğlu A, Dirim E, Ünver S, Ertek M (2020) Five-year period evaluation of isolated agents and their resistance profiles in intensive care unit patients with malignancy. J Infect Dev Ctries 14:918-923. doi: 10.3855/jidc.12219
Section
Original Articles