Nitazoxanide against COVID-19 in three explorative scenarios

José Meneses Calderón; Ma. del Rocío  Figueroa Flores; Leopoldo Paniagua Coria; Jesús Carlos Briones Garduño; Jazmín  Meneses Figueroa; María José  Vargas Contretas; Lilia  de la Cruz Ávila; Salvador  Díaz Meza; Reynaldo Ramírez Chacón; Srivatsan Padmanabhan; Hugo Mendieta Zerón

doi:10.3855/jidc.13274

Nitazoxanide against COVID-19 in three explorative scenarios

Authors

José Meneses Calderón “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico
Ma. del Rocío Figueroa Flores Private Practice, Toluca, Mexico
Leopoldo Paniagua Coria “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico
Jesús Carlos Briones Garduño “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico
Jazmín Meneses Figueroa Faculty of Medicine, Autonomous University of the State of Mexico (UAEMéx), Toluca, Mexico
María José Vargas Contretas Faculty of Medicine, Autonomous University of the State of Mexico (UAEMéx), Toluca, Mexico
Lilia de la Cruz Ávila “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico
Salvador Díaz Meza “Dr. Nicolás San Juan” General Hospital, Toluca, Mexico
Reynaldo Ramírez Chacón Instituto de Seguridad Social al Servicio de los Trabajadores del Estado (ISSSTE), Tabasco, Mexico
Srivatsan Padmanabhan St. Joseph Medical Center, Tacoma, WA, United States
Hugo Mendieta Zerón “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico

DOI:

https://doi.org/10.3855/jidc.13274

Keywords:

Ambulatory treatment, internal medicine, nitazoxanide, pregnancy, SARS-CoV-2

Abstract

Introduction: Nitazoxanide has shown efficacy in vitro against coronavirus infections (MERS, SARS, SARS-CoV-2). The aim of this report is to describe the results of treating COVID-19 positive patients with nitazoxanide in three clinical settings: pregnancy/puerperium, hospitalized patients in an Internal Medicine Service and in an ambulatory setting.

Methodology: This was a prospective follow-up and report of COVID-19 cases in three different situations, pregnant women, hospitalized patients receiving medical attention in an Internal Medicine Service and ambulatory patients residing in Toluca City, and Mexico City.

Results: The experience with a first group of 20 women, pregnant (17) or in immediate puerperium (3) was successful in 18 cases with two unfortunate deaths. The five cases treated in an Internal Medicine service showed a positive outcome with two patients weaned from mechanical ventilation. Of the remaining 16 patients treated in an ambulatory setting, all got cured. Nitazoxanide seems to be useful against SARS-CoV-2, not only in an early intervention but also in critical condition as well as in pregnancy without undesired effects for the babies. As an adjunctive therapy budesonide was used that seems to contribute to the clinical improvement.

Conclusions: Nitazoxanide could be useful against COVID-19 as a safe and available regimen to be tested in a massive way immediately.

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Published

2020-09-30

How to Cite

Meneses Calderón J, Figueroa Flores M del R, Paniagua Coria L, Briones Garduño JC, Meneses Figueroa J, Vargas Contretas MJ, de la Cruz Ávila L, Díaz Meza S, Ramírez Chacón R, Padmanabhan S, Mendieta Zerón H (2020) Nitazoxanide against COVID-19 in three explorative scenarios. J Infect Dev Ctries 14:982–986. doi: 10.3855/jidc.13274

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Issue

Vol. 14 No. 09: September 2020

Section

Coronavirus Pandemic

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