Multidrug resistance bacteremia in neonates and its association with late-onset sepsis and Coagulase-negative Staphylococci

  • Antonio M Quispe Universidad Continental, Huancayo, Peru
  • Gabriela Soza Instituto Nacional Materno Perinatal, Lima, Peru
  • Maria Ramos Chirinos Instituto Nacional Materno Perinatal, Lima, Peru
  • Danny Quiroz Instituto Nacional Materno Perinatal, Lima, Peru
  • Maria J Pons Universidad Científica del Sur, Lima, Peru
Keywords: Neonatal Sepsis, Drug Resistance, Microbial, Anti-Bacterial Agents, Bacteremia

Abstract

Introduction: This study aimed to assess the association between multidrug resistance (MDR) and late-onset sepsis (LOS) among newborns with bloodstream infection (BSI).

Methodology: In this cross-sectional study, we routinely tested every newborn with a presumptive diagnosis of sepsis admitted to the largest reference maternity hospital in Lima, Peru for BSI over an 18-month period. We tested every isolate for MDR by using the disk-diffusion method and assessed its associated factors by using a robust Poisson regression analysis with a particular focus on its association with LOS (vs. early-onset sepsis, EOS).

Results: We analyzed a total of 489 subjects, including 340 (69%) newborns with LOS, and estimated an MDR rate of 80% (95% confidence interval, CI: 76%-83%), which was significantly higher (p-value < 0.001) among LOS (85%; 95% CI: 81%-89%) than EOS cases (67%; 95% CI: 59%-75%). The primary isolate was coagulase-negative Staphylococci (CoNS) (60%), which exhibited a limited subset of antibiotic MDR patterns, most of which were characterized by their resistance to cefoxitin, gentamicin, and clindamycin and levofloxacin. Overall, the prevalence of MDR was higher among LOS compared to EOS cases (adjusted prevalence ratio [aPR] = 1.28; 95% CI: 1.14-1.45), and among BSI due to CoNS compared to other bacteria (Apr = 1.10; 95% CI: 1.01-1.20).

Conclusions: MDR among newborns with sepsis is exceptionally high, being even higher among those with LOS than newborns with EOS, and among those infected with CoNS compared to other bacteria. Furthermore, CoNS exhibited a limited subset of MDR patterns, which could be used to guide therapeutic decisions.

Published
2020-11-30
How to Cite
1.
Quispe AM, Soza G, Ramos Chirinos M, Quiroz D, Pons MJ (2020) Multidrug resistance bacteremia in neonates and its association with late-onset sepsis and Coagulase-negative Staphylococci. J Infect Dev Ctries 14:1256-1263. doi: 10.3855/jidc.12568
Section
Original Articles