Hematological parameters in patients with bloodstream infection: A retrospective observational study

  • Wei Tang Department of Clinical Laboratory, Second Hospital of Anhui Medical University, Hefei, Anhui, China
  • Wanchun Zhang Department of Gynecology and Obstetrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
  • Xin Li Department of Clinical Laboratory, Second Hospital of Anhui Medical University, Hefei, Anhui, China
  • Juan Cheng Department of Clinical Laboratory, Second Hospital of Anhui Medical University, Hefei, Anhui, China
  • Zhou Liu Department of Clinical Laboratory, Second Hospital of Anhui Medical University, Hefei, Anhui, China
  • Qiang Zhou Department of Clinical Laboratory, Second Hospital of Anhui Medical University, Hefei, Anhui, China
  • Shihe Guan Department of Clinical Laboratory, Second Hospital of Anhui Medical University, Hefei, Anhui, China
Keywords: bloodstream infection, blood cultures, hematological parameters, differential ability

Abstract

Introduction: To date, the relationship between the causative pathogens and the changes of hematological parameters was rarely referred and deserves further investigation.

Methodology: A total of 825 adult patients, including 134 negative blood cultures patients and 691 bloodstream infection (BSI) patients, were screened for eligibility in this study. Receiver operating characteristic curves and binary logistic regression models were used to assess the power of hematological parameters to distinguish patients with BSI caused by different pathogens.

Results: Except for platelet-to-lymphocyte ratio (PLR) and platelet larger cell count (P-LCC), the other hematological parameters investigated in the study were significantly different in patients with BSI caused by different pathogens, including Candida. The specific combinations of lymphocyte count (LYM), platelet count (PLT), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), MPV-to-PLT ratio (MPV/PLT), platelet larger cell ratio (P-LCR), and C-reactive protein (CRP) can improve the ability to distinguish various BSI from negative blood cultures. The highest area under the curve of was 0.753 (95% CI 0.709-0.797) for positive blood cultures, 0.715 (95% CI 0.658-0.771) for Gram-positive pathogens BSI, 0.777 (95% CI 0.730-0.824) for Gram-negative pathogens BSI, 0.797 (95% CI 0.747-0.846) for Escherichia coli BSI, 0.943 (95% CI 0.899-0.987) for Enterobacter aerogenes BSI, 0.830 (95% CI 0.740-0.921) for Pseudomonas aeruginosa BSI, and 0.767 (95% CI 0.695-0.839) for Staphylococcus aureus BSI.

Conclusions: The specific combinations of hematological parameters can improve the power to distinguish patients with BSI caused by different pathogens. Attention to these parameters can be easily integrated into daily medical activities, without extra costs.

Published
2020-11-30
How to Cite
1.
Tang W, Zhang W, Li X, Cheng J, Liu Z, Zhou Q, Guan S (2020) Hematological parameters in patients with bloodstream infection: A retrospective observational study. J Infect Dev Ctries 14:1264-1273. doi: 10.3855/jidc.12811
Section
Original Articles