Associated factors of Acinetobacter baumannii complex in hospitalized patients: A case-control study

  • Débora Fiorentin Vandresen Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil https://orcid.org/0000-0001-7091-9504
  • Léia Carolina Lucio Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil https://orcid.org/0000-0002-8094-4188
  • Roberto Shigueyasu Yamada Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil
  • Ana Paula Vieira Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil
  • Franciele Ani Caovilla Follador Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil https://orcid.org/0000-0002-9210-1540
  • Volmir Pitt Benedetti Faculty of Pharmacy, Paranaense University (UNIPAR), Francisco Beltrão, Brazil
  • Kérley Pereira Bento Casaril Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil
  • Cleide Viviane Buzanello Martins Postgraduate Program in Applied Health Sciences, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil https://orcid.org/0000-0003-0353-4721
  • Guilherme Welter Wendt Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil
  • Lirane Elize Defante Ferreto Health Sciences Center, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil https://orcid.org/0000-0002-0757-3659
Keywords: Acinetobacter baumannii, Hospital Infection, Multiple Bacterial Pharmacoresistence

Abstract

Introduction: Acinetobacter baumannii complex are microorganisms of critical priority of resistance, being associated with higher costs and negative outcomes for hospitalized patients. Thus, the study aimed to analyse the factors associated with A. baumannii complex infection in various hospital sectors.

Methodology: This is a case-control study that included patients hospitalized from January 2017 to June 2019. Demographic, microbiological and clinical variables were collected from each patient. All cases had positive culture results for A. baumannii complex resistant to more than three classes of antimicrobials. Carbapenem-resistance was examined by the disk diffusion test, while the broth microdilution method was used to determine the susceptibility to colistin.

Results: A. baumannii complex infection was mostly present in ICU (74.2%) than in other hospital areas. The bacteria was also linked with the length of hospitalization until the results for the culture (OR = 1.13; 95% CI: 1.06 – 1.21; p < 0.001) and with pneumonia associated with mechanical ventilation (OR = 4.48; 95% CI: 1.55 – 13.00; p = 0.006). Moreover, patients exposed to infection with multidrug-resistant A. baumannii complex had higher risks of death (OR = 3.25; 95% CI: 1.06 – 9.91; p = 0.039).

Conclusions: This study provides evidence that A. baumannii complex infection is associated with the number of days of hospitalization up to culture positivity, pneumonia associated with the use of mechanical ventilation and death. Infections appear to be more critical in ICU when compared to other areas. Taken together, these findings could support hospital infection surveillance programs, as well as prevention measures to reduce mortality rates and other complications.

Published
2021-01-31
How to Cite
1.
Fiorentin Vandresen D, Carolina Lucio L, Shigueyasu Yamada R, Paula Vieira A, Ani Caovilla Follador F, Pitt Benedetti V, Pereira Bento Casaril K, Viviane Buzanello Martins C, Welter Wendt G, Elize Defante Ferreto L (2021) Associated factors of Acinetobacter baumannii complex in hospitalized patients: A case-control study. J Infect Dev Ctries 15:73-80. doi: 10.3855/jidc.13525
Section
Original Articles