Hepatitis D virus antibodies and liver function profile among patients with chronic hepatitis B infection in Abuja, Nigeria

  • Lukman O Abdulkareem Department of Internal Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria
  • Dennis A Ndububa Department of Internal Medicine, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria
  • Augustine O Uhunmwangho Department of Internal Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria
  • Thahir Yunusa Department of Microbiology, University of Abuja Teaching Hospital, Abuja, Nigeria
Keywords: Hepatitis B, Hepatitis D, antibodies, liver function, Nigeria

Abstract

Introduction: Hepatitis D virus (HDV) is a satellite virus of hepatitis B virus (HBV). An estimated 5% of HBV infected individuals worldwide have HDV infection. There is paucity of studies in Nigeria on the burden of HDV infection. This study aimed at determining the prevalence rate of HDV antibodies among individuals with chronic hepatitis B (CHB) infection and comparing the liver function test (LFT) and disease severity among the anti-HDV positive (anti-HDV+) and anti-HDV negative (anti-HDV-) individuals.

Methodology: A cross-sectional study of 180 CHB infected individuals who were clinically evaluated and tested for HDV antibodies using the Enzyme-linked Immunoassay method. Their LFT profile and Child-Turcotte-Pugh (CTP) were also assessed. Data were analyzed using the SPSS version 17.

Results: Their mean age was 35.2 ± 10.4 years. There were 150 (83.3%) and 30 (16.7%) individuals with uncomplicated and complicated CHB infection respectively. Thirty-four (18.9%) of the participants were anti-HDV+. The mean serum ALT, AST, albumin and INR of the anti-HDV+ subjects were 16.5 ± 13.8 IU/L, 26.3 ± 32.6 IU/L, 38.9 ± 7.6 g/L, and 1.2 ± 0.2 respectively. The mean values for the same parameters of the anti-HDV- subjects were 10.8 ± 9.5 IU/L, 13.4 ± 11.2 IU/L, 41.4 ± 6.0 g/L and 1.1 ± 0.2 respectively (p < 0.05). The mean CTP scores in the anti-HDV+ and anti-HDV- subjects were 6.1 ± 2.1 and 5.5 ± 1.2 respectively (p= 0.03).

Conclusions: Anti-HDV sero-prevalence rate was 18.9% and anti-HDV+ CHB patients had worse LFT results compared to those who were anti-HDV–.

Author Biographies

Dennis A Ndububa, Department of Internal Medicine, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria

Professor of Medicine/ Consultant Gastroenterologist, Department of Internal Medicine

Augustine O Uhunmwangho, Department of Internal Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria

Consultant Gastroenterologist, Department of Internal Medicine

Thahir Yunusa, Department of Microbiology, University of Abuja Teaching Hospital, Abuja, Nigeria

Consultant Microbiologist, Department of Microbiology

Published
2021-01-31
How to Cite
1.
Abdulkareem LO, Ndububa DA, Uhunmwangho AO, Yunusa T (2021) Hepatitis D virus antibodies and liver function profile among patients with chronic hepatitis B infection in Abuja, Nigeria. J Infect Dev Ctries 15:141-146. doi: 10.3855/jidc.13127
Section
Original Articles