Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis

  • Alexander Edo Tondas Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia
  • Rido Mulawarman Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia https://orcid.org/0000-0003-2169-0971
  • Monica Trifitriana Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia https://orcid.org/0000-0002-9454-1961
  • Siti Nurmaini Intelligent System Research Group, Universitas Sriwijaya, Palembang, Indonesia https://orcid.org/0000-0002-8024-2952
  • Irfannuddin Irfannuddin Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia
Keywords: COVID-19, SARS-CoV-2, arrhythmia, ventricular repolarization, ECG, meta-analysis, T-peak-to-T-end

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias. Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19.

Methodology: We performed a comprehensive systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and Google Scholar Preprint Servers. The primary endpoints of this search were: Tp-e (T-peak-to-T-end) interval, QTd (QT dispersion), and Tp-e/QTc ratio in patients with newly diagnosed COVID-19 from inception up until August 2020.

Results: There were a total of 241 patients from 2 studies. Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group (mean difference 0.02 [0.01, 0.02], p < 0.001; I2: 18%,). Tp-e interval was more prolonged in COVID-19 group (mean difference 7.76 [3.11, 12.41], p < 0.001; I2: 80%) compared to control group. QT dispersion (QTd) also was increased in COVID-19 group (mean difference 1.22 [0.61, 1.83], p < 0.001 ; I2:30%).

Conclusions: Several electrocardiographic markers including Tp-e/QTc, Tp-e interval, and QTd are significantly increased in patients with COVID-19.

Published
2021-03-07
How to Cite
1.
Tondas AE, Mulawarman R, Trifitriana M, Nurmaini S, Irfannuddin I (2021) Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis. J Infect Dev Ctries 15:224-229. doi: 10.3855/jidc.13922
Section
Coronavirus Pandemic