Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis

Alexander Edo Tondas; Rido Mulawarman; Monica Trifitriana; Siti Nurmaini; Irfannuddin Irfannuddin

doi:10.3855/jidc.13922

Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis

Authors

Alexander Edo Tondas Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia
Rido Mulawarman Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia https://orcid.org/0000-0003-2169-0971
Monica Trifitriana Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia https://orcid.org/0000-0002-9454-1961
Siti Nurmaini Intelligent System Research Group, Universitas Sriwijaya, Palembang, Indonesia https://orcid.org/0000-0002-8024-2952
Irfannuddin Irfannuddin Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia

DOI:

https://doi.org/10.3855/jidc.13922

Keywords:

COVID-19, SARS-CoV-2, arrhythmia, ventricular repolarization, ECG, meta-analysis, T-peak-to-T-end

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias. Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19.

Methodology: We performed a comprehensive systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and Google Scholar Preprint Servers. The primary endpoints of this search were: Tp-e (T-peak-to-T-end) interval, QTd (QT dispersion), and Tp-e/QTc ratio in patients with newly diagnosed COVID-19 from inception up until August 2020.

Results: There were a total of 241 patients from 2 studies. Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group (mean difference 0.02 [0.01, 0.02], p < 0.001; I²: 18%,). Tp-e interval was more prolonged in COVID-19 group (mean difference 7.76 [3.11, 12.41], p < 0.001; I²: 80%) compared to control group. QT dispersion (QTd) also was increased in COVID-19 group (mean difference 1.22 [0.61, 1.83], p < 0.001 ; I²:30%).

Conclusions: Several electrocardiographic markers including Tp-e/QTc, Tp-e interval, and QTd are significantly increased in patients with COVID-19.

Downloads

Published

2021-03-07

How to Cite

Tondas AE, Mulawarman R, Trifitriana M, Nurmaini S, Irfannuddin I (2021) Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis. J Infect Dev Ctries 15:224–229. doi: 10.3855/jidc.13922

Download Citation

Endnote/Zotero/Mendeley (RIS)

Issue

Vol. 15 No. 02: February 2021

Section

Coronavirus Pandemic

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).