Kawasaki like illness due to COVID-19: a review of the literature

  • Yulin Fang Ministry of Health Holdings, Singapore
  • Veeraraghavan Meyyur Aravamudan Department of Medicine, Woodlands Health Campus, Singapore
  • Gurusaravanan Kutti Sridharan Banner University Medical Centre, University of Arizona, Tucson, AZ, United States
  • Keyur Kamlesh Mehta Children’s Heart Institute, The Heart Program at Inova Children’s Hospital, VA, United States
  • Ramkumar Sekhar Department of Cardiology, Khoo Teck Puat Hospital, Singapore
  • Nagendra Boopathy Senguttuvan Sri Ramachandra Medical College and Research Institute, Chennai, India
  • Indumathi Venkatachalam Department of Infectious Disease, Singapore General Hospital, Singapore
  • Muhammad Bilal Abid Divisions of Infectious Diseases and Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, United States
Keywords: Kawasaki-like disease, COVID-19, SARS-COV-2

Abstract

Introduction: Viral infections have been described as triggers for Kawasaki Disease (KD), a medium vessel vasculitis that affects young children. Akin to the H1N1 pandemic in 2009, there is a similar rise in the incidence of KD in children affected with Coronavirus disease 2019 (COVID-19). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been reported to induce an exaggerated systemic inflammatory response resulting in multi-organ involvement, particularly initiated with pulmonary parenchymal damage. This review article will discuss KD-like manifestations in COVID-19 patients in the pediatric cohort.

Methodology: Search terms “Kawasaki” “COVID-19” “SARS-COV-2” “PIM-TS” and “MIS-C” were used to look for relevant articles in PubMed and Google Scholar published in the last 5 years.

Results: There is some evidence to suggest that SARS-CoV-2 stimulates dysfunctional and hyperactive immune reactions mimicking KD in young patients.

Conclusions: Therapeutic options, both investigational and repurposed, include intravenous immunoglobulins, steroids and anticoagulation. More studies are required to evaluate the effectiveness of these treatment options.

Published
2021-05-31
How to Cite
1.
Fang Y, Aravamudan VM, Sridharan GK, Mehta KK, Sekhar R, Senguttuvan NB, Venkatachalam I, Abid MB (2021) Kawasaki like illness due to COVID-19: a review of the literature. J Infect Dev Ctries 15:630-638. doi: 10.3855/jidc.14185
Section
Coronavirus Pandemic