Coinfection in SARS-CoV-2 Infected Children Patients

  • Ayşe Karaaslan Department of Pediatrics, Kartal Dr. Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey
  • Ceren Çetin Department of Pediatrics, Kartal Dr. Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey
  • Yasemin Akın Department of Pediatrics, Kartal Dr. Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey
  • Serap Demir Tekol Department of Microbiology, Kartal Dr. Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey
  • Elif Söbü Department of Pediatrics, Kartal Dr. Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey
  • Recep Demirhan Department of Chest Surgery, Kartal Dr. Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey
Keywords: SARS CoV-2, coinfection, children, respiratory pathogen

Abstract

Introduction: The aim of this study is to determine the coinfections with other respiratory pathogens in SARS-CoV-2 infected children patients in a pediatric unit in Istanbul.

Methodology: This retrospective descriptive study was conducted in a 1000-bedded tertiary education and research hospital in Istanbul. All children hospitalized with the diagnosis of SARS-CoV-2 infection had been investigated for respiratory agents in nasopharyngeal secretions. Laboratory confirmation of SARS-CoV-2 and the other respiratory pathogens were performed using reverse transcriptase-polymerase chain reaction (RT-PCR).

Results: A total of 209 hospitalized children with suspected SARS-CoV-2 infection between March 2020-May 2020 were enrolled in this study. Among 209 children, 93 (44.5%) were RT-PCR positive for SARS-CoV-2 infection, and 116 (55.5%) were RT-PCR negative. The most common clinical symptoms in all children with SARS-CoV-2 infection were fever (68.8%) and cough (57.0%). The other clinical symptoms in decreasing rates were headache (10.8%), myalgia (5.4%), sore throat (3.2%), shortness of breath (3.2%), diarrhea (2.2%) and abdominal pain in one child. In 7 (7.5%) patients with SARS-CoV-2 infection, coinfection was detected. Two were with rhinovirus/enterovirus, two were with Coronavirus NL63, one was with adenovirus, and one was with Mycoplasma pneumoniae. In one patient, two additional respiratory agents (rhinovirus/enterovirus and adenovirus) were detected. There was a significantly longer hospital stay in patients with coinfection (p = 0.028).

Conclusions: Although the coinfection rate was low in SARS-CoV-2 infected patients in our study, we found coinfection as a risk factor for length of hospital stay in the coinfected patient group.

Published
2021-06-30
How to Cite
1.
Karaaslan A, Çetin C, Akın Y, Demir Tekol S, Söbü E, Demirhan R (2021) Coinfection in SARS-CoV-2 Infected Children Patients. J Infect Dev Ctries 15:761-765. doi: 10.3855/jidc.14314
Section
Coronavirus Pandemic