Tuberculosis and associated risk factors among children and adolescent population in Serbia: 12 year’s retrospective study

  • Maja B Stosic Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”, Belgrade, Serbia
  • Lidija Sagic Municipality Institute for Lung Diseases and Tuberculosis, Belgrade, Serbia
  • Danijela Simic Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”, Belgrade, Serbia
  • Verica Jovanovic Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”, Belgrade, Serbia
  • Violeta Rakic Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”, Belgrade, Serbia
  • Tatjana Adzic Vukicevic University Clinic for Pulmonology, Clinical Center of Serbia, Belgrade, Serbia
Keywords: tuberculosis, children, adolescents, Serbia, risk factors

Abstract

Introduction: Recognition and epidemiological control of childhood and adolescent tuberculosis (TB) is essential to achieve effective control of TB in general as it presents high risk for transmission in the community. The aim of the study is to provide a descriptive and analytic overview of the trends in childhood and adolescent TB notifications and treatment outcomes and to identify factors associated with treatment success in a twelve-year period in Serbia.

Methodology: We performed a retrospective trend analysis and analysis of treatment outcomes of 596 child and adolescent TB cases notified in Serbia in the period 2005–2016 from all health facilities, as well as logistic regression analysis to identify predictors of treatment success.

Results: Factors independently associated with treatment success were: new TB (OR=2.60; 95% CI: 1.45–3.74), male sex (OR=2.55; 95% CI: 2.09–3.00), pulmonary TB (OR=3.34; 95% CI: 2.34–4.34), comorbidities (OR=2.58; 95% CI: 2.24–2.91), age below 5 years (OR=0.37; 95% CI: 0.32–0.43), and social vulnerability (OR=0.40; 95% CI: 0.34–0.46).

Conclusions: In order to improve TB treatment outcomes among children and adolescent population in Serbia, it is important to focus on female, age group 5-18, EPTB, retreatment cases and socially vulnerable groups.

Published
2021-06-30
How to Cite
1.
Stosic MB, Sagic L, Simic D, Jovanovic V, Rakic V, Adzic Vukicevic T (2021) Tuberculosis and associated risk factors among children and adolescent population in Serbia: 12 year’s retrospective study. J Infect Dev Ctries 15:818-825. doi: 10.3855/jidc.14451
Section
Original Articles