Focusing on Asthma and Chronic Obstructive Pulmonary Disease with COVID-19

  • Bilun Gemicioglu Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey
  • Hafize Uzun Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey
  • Sermin Borekci Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey
  • Ridvan Karaali Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey
  • Sebuh Kurugoglu Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Radiology, Istanbul, Turkey
  • Pınar Atukeren Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey
  • Sabri Sirolu Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Radiology, Istanbul, Turkey
  • Sinem Durmus Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey
  • Ahmet Dirican Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Biostatistic, Istanbul, Turkey
  • Mert Ahmet Kuskucu Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Microbiology, Istanbul, Turkey
  • Fehmi Tabak Istanbul University–Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey
Keywords: Asthma, COPD, COVID-19 symptoms,, biochemical parameters, RT-PCR, Chest CT

Abstract

Introduction: We aimed to evaluate clinical and laboratory findings of hospitalized asthma and chronic obstructive pulmonary disease (COPD) patients with COVID-19 and demonstrate that they have different symptoms and/or laboratory results and outcomes than COVID-19 patients with comorbidity (CoV-com) and without comorbidity (CoV-alone).

Methodology: The data of the demographic, clinical, laboratory findings of hospitalized CoV-alone, asthma, COPD patients with COVID-19 (CoV-asthma, CoV-COPD, respectively), and CoV-com were analyzed.

Results: Out of 1082 patients hospitalized for COVID-19, 585 (54.1%) had CoV-alone, 40 (3.7%) had CoV-asthma, 46 (4.3%) had CoV-COPD and 411 (38%) had CoV-com. Cough, shortness of breath, fever and weakness were the most common four symptoms seen in all COVID-19 patients. Shortness of breath, myalgia, headache symptoms were more common in CoV-asthma than the other groups (p < 0.001, p < 0.01, p < 0.05 respectively). Sputum was more common in CoV-COPD than other groups (p < 0.01). COPD group most frequently had increased values, different from the other groups with CRP>5ng/mL in 91.3%, D-dimer > 0.05mg/dL in 89.1%, troponin > 0.014micg/L in %63.9, INR>1.15 in 52.2%, CK-MB>25U/L in 48.5%, PT>14s in 40.9% of patients (p < 0.05, p < 0.001, p < 0.001, p < 0.001, p < 0.05, p < 0.001, respectively). NT-ProBNP was found to have the highest AUC value and the best differentiating parameter for CoV-asthma from CoV-alone. Typical CT findings were present in 44.4% of CoV-alone, 57.5% of CoV-asthma, 28.3% of CoV-COPD and 38.9% of CoV-com groups. CoV-COPD and CoV-com patients died more frequently than other groups (17.8%, 18.5%).

Conclusions: CoV-asthma and CoV-COPD patients might have different symptoms and laboratory parameters than other COVID-19 patients which can guide the physicians.

Published
2021-10-31
How to Cite
1.
Gemicioglu B, Uzun H, Borekci S, Karaali R, Kurugoglu S, Atukeren P, Sirolu S, Durmus S, Dirican A, Kuskucu MA, Tabak F (2021) Focusing on Asthma and Chronic Obstructive Pulmonary Disease with COVID-19. J Infect Dev Ctries 15:1415-1425. doi: 10.3855/jidc.14611
Section
Coronavirus Pandemic