Sensitivity of Guillain-Barre Syndrome Surveillance in the Brazilian Federal District, using the Capture-Recapture Method

  • Ana Flavia de Morais Oliveira Federal Institute of Education, Science and Technology of Tocantins – IFTO - Araguaína, TO, Brazil
  • Luciana Guerra Gallo Graduate Program in Tropical Medicine, University of Brasilia. Center for Tropical Medicine, Brasília, DF, Brazil
  • Mábia Milhomem Bastos Zika and other Arbovirus Cohort Studies – ZARICS, University of Brasília. Center for Tropical Medicine, Brasília, DF, Brazil
  • Amanda Amaral Abrahão Brazilian Ministry of Health, Brasília, DF, Brazil
  • Paulo Rufalco-Moutinho Zika and other Arbovirus Cohort Studies – ZARICS, University of Brasília. Center for Tropical Medicine, Brasília, DF, Brazil
  • Juliane Maria Alves Siqueira Malta Brazilian Ministry of Health, Brasília, DF, Brazil
  • Klauss Kleydmann Sabino Garcia Graduate Program in Tropical Medicine, University of Brasilia. Center for Tropical Medicine, Brasília, DF, Brazil
  • Luiza Morais de Matos Department of Infectious Diseases at Hospital Materno Infantil de Brasília, DF, Brazil
  • Wildo Navegantes de Araújo Graduate Program in Tropical Medicine, University of Brasilia. Center for Tropical Medicine, Brasília, DF, Brazil
Keywords: arboviruses, surveillance system, Guillain-Barre Syndrome

Abstract

Introduction: Guillain-Barre Syndrome (GBS) is an acute immune-mediated polyneuropathy that compromises the peripheral and cranial nerves. It is characterized by rapid-onset paresthesia accompanied by progressive weakness in the lower extremities followed by symmetric ascending paralysis.

Methodology: assessment of sensitivity to detect GBS between March 2017 and May 2019 in a public referral hospital, using the capture-recapture method based on the Chapman estimator and comparing three GBS data sources: the hospital-based sentinel surveillance system (VSBH), Human Immunoglobulin Dispensing Records System (RDIH), and Hospital Information System (SIH).

Results: A total of 259 possible cases were identified (captured). Of these, 58 were confirmed and most resided in the Federal District. The VSBH showed the greatest sensitivity in case identification. The temporal distribution of cases showed periods with no cases identified, and more were registered during the rainy season from October to May, when high temperatures also occur.

Conclusions: Increased circulation of arboviruses and gastrointestinal infections during the rainy season may explain the greater concentration of GBS cases. It is important to note that one-third of the cases identified in the different data sources do not converge, demonstrating that no single surveillance system is 100% effective. The severity and possible increase in cases related to GBS demonstrates the need for an improved surveillance system capable of monitoring and following-up cases involving neurological syndromes, regardless of the event preceding infection.

Published
2021-10-31
How to Cite
1.
de Morais Oliveira AF, Gallo LG, Bastos MM, Abrahão AA, Rufalco-Moutinho P, Malta JMAS, Garcia KKS, Matos LM de, Araújo WN de (2021) Sensitivity of Guillain-Barre Syndrome Surveillance in the Brazilian Federal District, using the Capture-Recapture Method. J Infect Dev Ctries 15:1507-1514. doi: 10.3855/jidc.13457
Section
Original Articles