Evaluation of respiratory anatomical-functional sequelae in patients who recovered from COVID-19

  • Margarita de la Luz Martinez-Fierro Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Jose Isaias Badillo-Almaraz Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Jose Ramon Muñoz-Torres Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Griselda Aide Cabral Pacheco Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Idalia Garza-Veloz Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Edgar Fernando Gutierrez-Vela General Hospital of Zacatecas "Luz González Cosío", Zacatecas Health Services, Zacatecas, México
  • Lucia Socorro Hernandez-Marquez Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Lizbeth Areli Hernandez-Marquez Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Alondra Daniela Torres-Gaytan Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Juan Carlos Alvarez-Castro Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Claudia Caldera-Villalobos Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Ivan Delgado-Enciso Department of Molecular Medicine, School of Medicine, University of Colima, Colima, Mexico
  • Iram Pablo Rodriguez-Sanchez Molecular and Structural Physiology Laboratory, School of Biological Sciences, Autonomous University of Nuevo León, Monterrey, Nuevo León, Mexico
  • Oscar Gustavo Meza-Zavala Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
  • Yolanda Ortiz-Castro Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico
Keywords: pulmonary sequelae, SARS-CoV-2, COVID-19, coronavirus, computerized tomography scan

Abstract

Introduction: Coronavirus disease 19 (COVID-19) has been a global public health emergency, with 209.89 million cases of infection with SARS-CoV-2 recorded, resulting in 4,401,675 deaths. After recuperation, it is probable that COVID-19 patients have sequelae of the disease. This study aimed to evaluate the respiratory anatomical–functional sequelae in Mexican patients who recovered from COVID-19.

Methodology: This study included twenty-four patients who recovered from COVID-19 and eight non-infected patients (controls). Participants were screened for SARS-CoV-2 and the presence of IgM/IgG antibodies. Pulmonary function and lung anatomical abnormalities were evaluated by spirometry and computerized tomography.

Results: A total of 45.8% of the patients had pulmonary function with obstructive patterns: 70.8% of recovered cases had COVID-19 Reporting and Data System (CO-RADS) 1, 20.8% CO-RADS 3 and 16.7% CO-RADS 4. A total of 35.3% of patients with CO-RADS 1 also showed bilateral nodal growth; 70.8% of patients tested positive for IgG and 8.4% for IgG/IgM, and 20.8% tested negative for both antibodies.

Conclusions: There were respiratory anatomical and functional sequelae in Mexican patients who recovered from COVID-19, with a high occurrence of pulmonary obstructive patterns in the study population. These observations indicate the importance of the routine evaluation of sequelae in Mexican patients who recovered from COVID-19 and the need for strict follow-up to improve the quality of life of these patients.

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Published
2022-01-31
How to Cite
1.
Martinez-FierroM de la L, Badillo-AlmarazJI, Muñoz-TorresJR, Cabral PachecoGA, Garza-VelozI, Gutierrez-VelaEF, Hernandez-MarquezLS, Hernandez-MarquezLA, Torres-GaytanAD, Alvarez-CastroJC, Caldera-VillalobosC, Delgado-EncisoI, Rodriguez-SanchezIP, Meza-ZavalaOG, Ortiz-CastroY (2022) Evaluation of respiratory anatomical-functional sequelae in patients who recovered from COVID-19. J Infect Dev Ctries 16:73-80. doi: 10.3855/jidc.13772
Section
Coronavirus Pandemic

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