Cumulative effects of hypertriglyceridemia in HIV-infected patients switching from NNRTIs to PI-based antiretroviral therapy

Yu Zhang; Jiang Xiao; Wen Zhang; Ning Han; Di  Yang; Wei Liu; Hui  Zeng; Junyan  Han; Hongxin Zhao

doi:10.3855/jidc.12519

Cumulative effects of hypertriglyceridemia in HIV-infected patients switching from NNRTIs to PI-based antiretroviral therapy

Authors

Yu Zhang Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Jiang Xiao Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Wen Zhang Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Ning Han Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Di Yang Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Wei Liu Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Hui Zeng Institute of Infectious diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Junyan Han Institute of Infectious diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Hongxin Zhao Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

DOI:

https://doi.org/10.3855/jidc.12519

Keywords:

Non-nucleoside reverse transcriptase inhibitors, protease inhibitors, highly active antiretroviral therapy, hypertriglyceridemia

Abstract

Introduction: The objective of this study was to investigate changes in serum lipids among HIV-infected patients switching from non-nucleoside-reverse transcriptase inhibitors (NNRTI) to protease inhibitor (PI)-based highly active antiretroviral therapy (HAART), and to determine if changes of lipid profiles impacted the monocyte subsets recovery.

Methodology: Fifty-seven subjects who switched from NNRTIs to PI-based HAART (NNRTIs to PI group) and fifty-five subjects who initially started with PI-based HAART (initial PI group) were recruited. According to their baseline triglyceride (TG) levels, the NNRTIs to PI and initial PI groups were further divided into non-hypertriglyceridemia and hypertriglyceridemia subgroups, respectively. The effects of PI-based HAART on lipid profiles and monocyte subsets were analyzed.

Results: At 48 weeks, the TG changes in the NNRTIs to PI group was higher than that of the initial PI group. The increases of serum TG levels in the initial PI non-hypertriglyceridemia group was greater than that of the NNRTIs to PI non-hypertriglyceridemia group. For the hypertriglyceridemia group at baseline, significant increment in TG levels were observed in the NNRTIs to PI hypertriglyceridemia group. The percentages of circulating CD14^highCD16⁺and CD14^lowCD16⁺ subsets were elevated in the two groups. At 48 weeks, the proportion of CD14^highCD16⁺monocytes declined gradually, and the proportion of CD14^lowCD16⁺ monocytes decreased independently of the TG level.

Conclusions: For non-hypertriglyceridemia individuals at baseline, PI-based regimens increased the TG level in the initial PI group. For the NNRTIs to PI hypertriglyceridemia group, PI-based regimens reinforced HAART-related hypertriglyceridemia.

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Published

2022-03-31

How to Cite

Zhang Y, Xiao J, Zhang W, Han N, Yang D, Liu W, Zeng H, Han J, Zhao H (2022) Cumulative effects of hypertriglyceridemia in HIV-infected patients switching from NNRTIs to PI-based antiretroviral therapy. J Infect Dev Ctries 16:528–536. doi: 10.3855/jidc.12519

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Issue

Vol. 16 No. 03: March 2022

Section

Original Articles

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