Challenges of the treatment of pediatric hepatosplenic bartonellosis: case report and literature review

  • Saliha Kanık-Yüksek Pediatric Infectious Diseases Department, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
  • Belgin Gülhan Pediatric Infectious Diseases Department, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
  • Selen Hürmüzlü Pediatric Diseases Department, University of Health Sciences, Ankara City Hospital, Turkey
  • Aslınur Özkaya-Parlakay Pediatric Infectious Diseases Department, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
  • Altan Güneş Pediatric Radiology Department, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
  • Ayşe Selcen Oğuz-Erdoğan Pathology Department, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
  • Hasan Tezer Pediatric Infectious Diseases Department, Gazi University Medical Faculty, Ankara, Turkey
Keywords: Bartonellosis, hepatosplenic, treatment

Abstract

The hepatosplenic (HS) form of cat scratch disease (CSD) is rarely seen; however, management of the treatment is challenging for clinicians. Monotherapy or combination regimens may be preferred based on severity of cases. Along with that, there are uncertainties as to the combination and duration of antibiotics effective against the microorganisms. In this report, a 12-year-old girl diagnosed with HS-CSD and unresponsive to primary treatment with macrolide group antibiotic was presented. The patient had liver findings compatible with CSD, confirmed radiologically and pathologically, and Bartonella henselae indirect immunofluorescence assay IgG was positive at 1/2048 titre. A combination therapy for six months with doxycycline and rifampicin was initiated, and the patient was successfully treated. The preference for monotherapy or combination regimen in HS-CSD is predominantly determined by the clinician according to the severity of the patient’s clinical findings. The effectivity of antimicrobial regimen in HS-CSD requires further investigation.

Published
2022-04-30
How to Cite
1.
Kanık-YüksekS, Gülhan B, Hürmüzlü S, Özkaya-ParlakayA, Güneş A, Oğuz-ErdoğanAS, Tezer H (2022) Challenges of the treatment of pediatric hepatosplenic bartonellosis: case report and literature review. J Infect Dev Ctries 16:712-716. doi: 10.3855/jidc.15042
Section
Case Reports