Fatal invasive candidiasis in COVID-19 patient with severe bleeding and extensively drug-resistant Klebsiella enterobacter

  • Tatjana Adzic-Vukicevic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Jelena Velickovic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Aleksandra Radovanovic-Spurnic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Dejan Velickovic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Sara Milenkovic Center for Radiology and NMR, University Clinical Center, Belgrade, Serbia
  • Filip Petrovic Clinic for Vascular Surgery, University Clinical Center, Belgrade, Serbia
  • Jelena Micic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Natasa Dragutinovic Department of Gastroenterology, Hepatology and GI Endoscopy, University Children's Hospital, Belgrade, Serbia
Keywords: COVID-19, candida, hemorrhage, operation, resistance

Abstract

Introduction: Multi-organ dysfunction caused by thromboembolic complications may complicate the course of SARS-CoV-2 infection. Most patients require anticoagulant therapy which predisposes them to the development of hemorrhagic syndrome. In critically ill COVID-19 patients secondary infections due to opportunistic pathogens are associated with a high mortality rate.

Case report: Herein, we present a COVID-19 patient with severe hemorrhage at unusual sites complicated with invasive candidiasis and an extensively drug-resistant (XDR) strain of Klebsiella enterobacter.

Conclusions: Clinicians should be aware of the possibility for invasive fungal infections in severely ill patients with SARS-CoV-2 infection due to pre-existing conditions, risk factors, and COVID-19 associated pathological mechanisms. Management of invasive candidiasis is challenging because of the high prevalence of comorbidities, risk of toxicities, and drug interactions.

Downloads

Download data is not yet available.
Published
2022-06-30
How to Cite
1.
Adzic-VukicevicT, Velickovic J, Radovanovic-SpurnicA, Velickovic D, Milenkovic S, Petrovic F, Micic J, Dragutinovic N (2022) Fatal invasive candidiasis in COVID-19 patient with severe bleeding and extensively drug-resistant Klebsiella enterobacter. J Infect Dev Ctries 16:1025-1029. doi: 10.3855/jidc.16256
Section
Coronavirus Pandemic

Most read articles by the same author(s)