Fatal invasive candidiasis in COVID-19 patient with severe bleeding and extensively drug-resistant Klebsiella enterobacter

Tatjana Adzic-Vukicevic; Jelena Velickovic; Aleksandra Radovanovic-Spurnic; Dejan Velickovic; Sara Milenkovic; Filip Petrovic; Jelena Micic; Natasa Dragutinovic

doi:10.3855/jidc.16256

Fatal invasive candidiasis in COVID-19 patient with severe bleeding and extensively drug-resistant Klebsiella enterobacter

Authors

Tatjana Adzic-Vukicevic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Jelena Velickovic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Aleksandra Radovanovic-Spurnic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Dejan Velickovic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Sara Milenkovic Center for Radiology and NMR, University Clinical Center, Belgrade, Serbia
Filip Petrovic Clinic for Vascular Surgery, University Clinical Center, Belgrade, Serbia
Jelena Micic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Natasa Dragutinovic Department of Gastroenterology, Hepatology and GI Endoscopy, University Children's Hospital, Belgrade, Serbia

DOI:

https://doi.org/10.3855/jidc.16256

Keywords:

COVID-19, candida, hemorrhage, operation, resistance

Abstract

Introduction: Multi-organ dysfunction caused by thromboembolic complications may complicate the course of SARS-CoV-2 infection. Most patients require anticoagulant therapy which predisposes them to the development of hemorrhagic syndrome. In critically ill COVID-19 patients secondary infections due to opportunistic pathogens are associated with a high mortality rate.

Case report: Herein, we present a COVID-19 patient with severe hemorrhage at unusual sites complicated with invasive candidiasis and an extensively drug-resistant (XDR) strain of Klebsiella enterobacter.

Conclusions: Clinicians should be aware of the possibility for invasive fungal infections in severely ill patients with SARS-CoV-2 infection due to pre-existing conditions, risk factors, and COVID-19 associated pathological mechanisms. Management of invasive candidiasis is challenging because of the high prevalence of comorbidities, risk of toxicities, and drug interactions.

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Published

2022-06-30

How to Cite

Adzic-Vukicevic T, Velickovic J, Radovanovic-Spurnic A, Velickovic D, Milenkovic S, Petrovic F, Micic J, Dragutinovic N (2022) Fatal invasive candidiasis in COVID-19 patient with severe bleeding and extensively drug-resistant Klebsiella enterobacter. J Infect Dev Ctries 16:1025–1029. doi: 10.3855/jidc.16256

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Issue

Vol. 16 No. 06: June 2022

Section

Coronavirus Pandemic

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