Molecular typing of dengue virus in Mizoram, Northeast India

Christine Vanlalbiakdiki Sailo; Souvik Ghatak; Subbarayan Sarathbabu; Girija Shankar Bariha; Ayan Majumder; Abhinav Singh; Ralte Lalremruata; Eric Zomawia; Benjamin Lalrinpuia; Lalfak zuali; John Zothanzama; Nachimuthu Senthil Kumar

doi:10.3855/jidc.16137

Molecular typing of dengue virus in Mizoram, Northeast India

Authors

Christine Vanlalbiakdiki Sailo Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India
Souvik Ghatak Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0003-3976-5345
Subbarayan Sarathbabu Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0003-3012-7486
Girija Shankar Bariha Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0003-3560-2434
Ayan Majumder Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0003-4533-8083
Abhinav Singh Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0001-9144-8246
Ralte Lalremruata Department of Microbiology, Synod Hospital, Durtlang, Aizawl, Mizoram, India https://orcid.org/0000-0003-4315-2365
Eric Zomawia Hospital and Medical Education, Department of Health and Family Welfare, Government of Mizoram, Aizawl, India https://orcid.org/0000-0003-2496-6849
Benjamin Lalrinpuia Department of Physiology, Zoram Medical College, Falkawn, Mizoram, India https://orcid.org/0000-0001-8524-7149
Lalfak zuali Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0002-2581-2836
John Zothanzama Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India
Nachimuthu Senthil Kumar Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India https://orcid.org/0000-0002-0192-2133

DOI:

https://doi.org/10.3855/jidc.16137

Keywords:

dengue, serotypes, co-infection, moist tropical, Northeast India

Abstract

Introduction: Dengue is an emerging vector-borne public health threat and characterization at the molecular level is important for proper management of the disease. The aim of the study is to examine the diversity of the dengue viral serotypes from a hilly mountainous region of Northeast India.

Methodology: Thirty-six blood samples that were positive for dengue virus IgM antibodies identified by the enzyme-linked immunosorbent assay (ELISA) method were collected and quantified for the IL6 gene expression by using reverse transcriptase polymerase chain reaction (RT-PCR).

Results: All the patients had dengue hemorrhagic fever (DHF); 12 samples had a monotypic infection and 14 samples had dual infection with various dengue virus (DENV) serotypes; one sample had triple infection with DENV-1, DENV-2, and DENV-3.

Conclusions: This study identified DENV-1 as the major serotype in the state of Mizoram and it is the first report on the molecular typing of the dengue virus from the hilly mountainous state located in the Indo-Burma region bordering Myanmar and Bangladesh.

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Published

2022-10-31

How to Cite

Sailo CV, Ghatak S, Sarathbabu S, Bariha GS, Majumder A, Singh A, Lalremruata R, Zomawia E, Lalrinpuia B, Lalfak zuali, Zothanzama J, Senthil Kumar N (2022) Molecular typing of dengue virus in Mizoram, Northeast India. J Infect Dev Ctries 16:1637–1642. doi: 10.3855/jidc.16137

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Issue

Vol. 16 No. 10: October 2022

Section

Original Articles

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