Severe acute respiratory syndrome by influenza and factors associated with death in older adults: a population study

Authors

  • Thayna Martins Gonçalves Medical School, Federal University of Uberlandia, Uberlandia, Brazil https://orcid.org/0000-0001-8256-8596
  • Patrícia Mitsue Saruhashi Shimabukuro Paulista Nursing School, Federal University of São Paulo, São Paulo, Brazil https://orcid.org/0000-0002-1431-0611
  • Karen Renata Nakamura Hiraki Institute of Biomedical Science, Federal University of Uberlandia, Uberlandia, Brazil
  • Paulo Henrique Braz-Silva Laboratory of Virology (LIM-52), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil https://orcid.org/0000-0002-1842-9521
  • Simone Giannecchini Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy https://orcid.org/0000-0003-3374-7621
  • Kelvin Kai-Wang To State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, Li KaShing Faculty of Medicine of the University of Hong Kong, Hong Kong, China
  • Monica Taminato Paulista Nursing School, Federal University of São Paulo, São Paulo, Brazil https://orcid.org/0000-0003-4075-2496
  • Richarlisson Borges de Morais Paulista Nursing School, Federal University of São Paulo, São Paulo, Brazil https://orcid.org/0000-0003-0009-1750

DOI:

https://doi.org/10.3855/jidc.16801

Keywords:

Influenza, death, risk factors, elderly, vaccine, infection

Abstract

Introduction: Influenza is characterized by an acute viral infection, which can lead to severe conditions and death, especially in vulnerable populations, such as older adults. Therefore, we sought to analyze cases of severe acute respiratory syndrome (SARS) due to influenza in older adults registered in Brazil and investigate the factors related to death due to this disease.

Methodology: This is a cross-sectional, population-based study that used secondary data from the Influenza Epidemiological Surveillance Information System (IESIS-Influenza). Older adults aged 60 years and above with laboratory diagnosis of influenza were included.

Results: A total of 3,547 older adults with SARS due to influenza were included, out of which 1,185 cases with death as the outcome were identified. Among older adults with death as the outcome, 87.4% were not vaccinated against influenza. The main risk factors for death were invasive ventilatory support use, intensive care unit admission, brown skin color and dyspnea (p < 0.001).

Conclusions: This study described the profile of older adults with SARS due to influenza in Brazil. Factors associated with death in this population were identified. Moreover, the need to encourage compliance with vaccination among older adults is evident in order to prevent severe cases and unfavorable outcomes related to influenza.

Author Biographies

Paulo Henrique Braz-Silva, Laboratory of Virology (LIM-52), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil

Laboratório de Virologia (LIM-52), Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.

Departamento de Estomatologia, Faculdade de Odontologia, Universidade de São Paulo, São Paulo, Brasil

 

Simone Giannecchini, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

Department of Experimental and Clinical Medicine, Universita degli Studi di Firenze, Florence, Italy.

Kelvin Kai-Wang To, State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, Li KaShing Faculty of Medicine of the University of Hong Kong, Hong Kong, China

Laboratório-chave do Estado para Doenças Infecciosas Emergentes, Departamento de Microbiologia, Faculdade de Medicina Li KaShing da Universidade de Hong Kong, Hong Kong, China.

Departamento de Microbiologia, Hospital Queen Mary, Hong Kong, China.

Departamento de Microbiologia Clínica e Controle de Infecções, Universidade de Hong Kong – Hospital de Shenzhen, Shenzhen, China

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Published

2023-02-28

How to Cite

1.
Martins Gonçalves T, Mitsue Saruhashi Shimabukuro P, Nakamura Hiraki KR, Braz-Silva PH, Giannecchini S, Kai-Wang To K, Taminato M, Borges de Morais R (2023) Severe acute respiratory syndrome by influenza and factors associated with death in older adults: a population study. J Infect Dev Ctries 17:241–250. doi: 10.3855/jidc.16801

Issue

Vol. 17 No. 02: February 2023

Section

Original Articles

License

Copyright (c) 2023 Thayna Martins Gonçalves, Patrícia Mitsue Saruhashi Shimabukuro , Karen Renata Nakamura Hiraki , Paulo Henrique Braz da Silva, Simone Giannecchini , Kelvin Kai-Wang To, Monica Taminato , Richarlisson Borges de Morais

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