Characterization of ESKAPE pathogens in urinary tract infections among Jordanian patients

Rawan H Alsharedeh; Alaa Yehya; Othman Beni Yonis; Omran Alameri; Nida Alshraiedeh

doi:10.3855/jidc.17490

Characterization of ESKAPE pathogens in urinary tract infections among Jordanian patients

Authors

Rawan H Alsharedeh Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan
Alaa Yehya Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Jordan
Othman Beni Yonis Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Omran Alameri Department of Basic Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan
Nida Alshraiedeh Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan

DOI:

https://doi.org/10.3855/jidc.17490

Keywords:

ESKAPE pathogens, UTIs, risk factors, antimicrobial resistance, Jordan

Abstract

Introduction: ESKAPE pathogens are a small group of pathogens of remarkable importance. The present study was carried out to determine the prevalence of ESKAPE pathogens in urinary tract infections (UTIs) and their antibiotic susceptibility patterns at the Jordan University of Science and Technology Health Center in Irbid, Jordan.

Methodology: A one-year retrospective study was conducted from April 2021 to April 2022. A total of 444 samples of “clean-catch” (midstream) urine from outpatients were studied.

Results: Our study showed that the vast majority of urinary tract infected patients were females (92%) compared to males (8%) and were most frequent in the age group 21-30 years old. The most associated co-morbidities with UTIs were hypertension followed by diabetes mellitus and hypothyroidism. ESKAPE pathogens were responsible for about 87.4% of the UTIs in this study, and all were identified in the urine samples except Acinetobacter baumannii. In this study, isolates were most sensitive to levofloxacin, ciprofloxacin, and third-generation cephalosporin's and least sensitive to doxycycline, amoxicillin, and clindamycin.

Conclusions: This research work has shown that patients with UTI-associated ESKAPE pathogens in Jordan are at high risk of antibiotic resistance. To the best of our knowledge, this is the first study in the region that studies the association between ESKAPE pathogens and UTIs.

Downloads

Published

2023-03-31

How to Cite

Alsharedeh RH, Yehya A, Beni Yonis O, Alameri O, Alshraiedeh N (2023) Characterization of ESKAPE pathogens in urinary tract infections among Jordanian patients. J Infect Dev Ctries 17:374–380. doi: 10.3855/jidc.17490

Download Citation

Endnote/Zotero/Mendeley (RIS)

Issue

Vol. 17 No. 03: March 2023

Section

Original Articles

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).