Severe acute respiratory syndrome coronavirus-2 antibody response after Moderna vaccine booster on healthcare providers

Fanny Fachrucha; Dianiati Kusumo Sutoyo; Fariz Nurwidya; Sita Laksmi Andarini; Agus Dwi Susanto; Fathiyah Isbaniah; Diah Handayani; Faisal Yunus; Dicky Soehardiman; Jamal Zaini; Silvana Saputri; Prasenohadi

doi:10.3855/jidc.17268

Severe acute respiratory syndrome coronavirus-2 antibody response after Moderna vaccine booster on healthcare providers

Authors

Fanny Fachrucha Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia https://orcid.org/0000-0001-9450-2180
Dianiati Kusumo Sutoyo Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Fariz Nurwidya Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Sita Laksmi Andarini Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-0169-1109
Agus Dwi Susanto Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Fathiyah Isbaniah Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Diah Handayani Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia https://orcid.org/0000-0002-3647-2670
Faisal Yunus Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Dicky Soehardiman Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Jamal Zaini Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Silvana Saputri Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia
Prasenohadi Department Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine – Persahabatan Hospital, Jakarta, Indonesia

DOI:

https://doi.org/10.3855/jidc.17268

Keywords:

COVID-19, vaccination, booster, Moderna, healthcare providers

Abstract

Introduction: As an endeavor to control SARS-CoV-2 infection, the Moderna vaccine booster was given to healthcare workers to prevent reinfection and reduce the risk of complications from COVID-19. A heterologous booster vaccine is also thought to provide better protection against the current SARS-CoV-2 variants of concern. However, research that evaluates the effectiveness of the Moderna vaccine booster and the resulting SARS-CoV-2 antibody concentration is needed.

Objective: To evaluate the concentration of SARS-CoV-2 antibodies after the Moderna vaccine booster and the severity of SARS-CoV-2 infection before and after the Moderna vaccine booster.

Results: A total of 93 healthcare providers who received Moderna vaccine booster were included in the study. Examination of antibody concentration 3 months after the booster showed an average concentration of 10081.65 U/mL. There was an increase in antibody concentration before the booster and 3 months after, from a median of 1.7 U/mL to 9540 U/mL. Every subject showed a statistically significant increment of antibody concentration 3 months after the booster (p < 0.01). Thirty-seven (39.8%) subjects received two doses of the Sinovac vaccine and were confirmed to have COVID-19 with the Delta variant. After the booster, 26 (28%) subjects were infected with the Omicron Variant. Among the subjects who received two doses of the Sinovac vaccine and were confirmed with COVID-19, 36 (30.1%) had mild symptoms, and 1 (1.1%) was asymptomatic.

Conclusions: Heterologous Moderna vaccine booster effectively increases antibody response against SARS-CoV-2 variants and shows mild symptoms of COVID-19 infection.

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Published

2023-05-31

How to Cite

Fachrucha F, Sutoyo DK, Nurwidya F, Andarini SL, Susanto AD, Isbaniah F, Handayani D, Yunus F, Soehardiman D, Zaini J, Saputri S, Prasenohadi (2023) Severe acute respiratory syndrome coronavirus-2 antibody response after Moderna vaccine booster on healthcare providers. J Infect Dev Ctries 17:617–622. doi: 10.3855/jidc.17268

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Issue

Vol. 17 No. 05: May 2023

Section

Coronavirus Pandemic

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Copyright (c) 2023 Fanny Fachrucha, Dianiati Kusumo Sutoyo, Fariz Nurwidya, Sita Laksmi Andarini, Agus Dwi Susanto, Fathiyah Isbaniah, Diah Handayani, Faisal Yunus, Dicky Soehardiman, Jamal Zaini, Silvana Saputri, Prasenohadi Prasenohadi

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