Antibiotic resistance patterns of pediatric community-acquired urinary tract infections in a tertiary care center in Jeddah, Saudi Arabia

Mohammed A Alsubaie; Abdullah Z Alsuheili; Mohammed N Aljehani; Abdulrahman A Alothman; Abdulaziz S Alzahrani; Hamza A Mohammedfadel; Mazin A Alshehry; Abeer A Alnajjar

doi:10.3855/jidc.17733

Antibiotic resistance patterns of pediatric community-acquired urinary tract infections in a tertiary care center in Jeddah, Saudi Arabia

Authors

Mohammed A Alsubaie Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0002-6098-0704
Abdullah Z Alsuheili Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0009-0002-2648-1052
Mohammed N Aljehani Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0001-8484-4099
Abdulrahman A Alothman Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0002-8227-6742
Abdulaziz S Alzahrani Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0002-6250-0364
Hamza A Mohammedfadel Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0003-2672-4202
Mazin A Alshehry Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0009-0005-7852-2807
Abeer A Alnajjar Infectious Diseases Unit, Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia https://orcid.org/0000-0002-0221-8535

DOI:

https://doi.org/10.3855/jidc.17733

Keywords:

Antibiotic resistance, urinary tract infections, pediatric, children, Escherichia coli

Abstract

Introduction: Urinary tract infections (UTIs) are common in children. UTIs can lead to serious and permanent damage to the urinary tract if treatment is delayed or insufficient, particularly in repeated infections. Knowledge of antibiotic resistance trends aids in the selection of appropriate empiric antibiotics. There is limited data regarding this in Saudi Arabia. This study aimed to investigate uropathogens and their antibiotic resistance patterns in the pediatric community in a tertiary care center.

Methodology: The study population included children aged 0 to 14 years old who had culture-proven UTIs evaluated in the Department of Pediatrics, King Abdulaziz University Hospital in Jeddah, Saudi Arabia from February 2019 to September 2021.

Results: Out of 510 UTI episodes, Escherichia coli (54.5%) was the predominant causative pathogen. Of the total episodes, 137 (26.8%) were caused by extended spectrum beta-lactamase (ESBL) producers. In general, the highest resistance was observed against ampicillin (73.2%), cefazolin (54.6%), co-trimoxazole (46%), and cefuroxime (40.6%), whereas amikacin (0.4%), imipenem (0.8%), and meropenem (0.8%) showed the lowest rates of resistance.

Conclusions: Antibiotic resistance is a major concern worldwide due to misuse of antibiotics and subsequent rise of multidrug resistant organisms. Our findings highlight the rise in antibiotic resistance, particularly in E. coli strains. Furthermore, ESBL-producing bacteria were responsible for approximately one-third of UTIs. Our study emphasizes the importance of local antibiograms for pediatric community-acquired infections, as it guides clinicians in every center in the choice of appropriate empiric antibiotic treatment.

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Published

2023-10-31

How to Cite

Alsubaie MA, Alsuheili AZ, Aljehani MN, Alothman AA, Alzahrani AS, Mohammedfadel HA, Alshehry MA, Alnajjar AA (2023) Antibiotic resistance patterns of pediatric community-acquired urinary tract infections in a tertiary care center in Jeddah, Saudi Arabia. J Infect Dev Ctries 17:1430–1435. doi: 10.3855/jidc.17733

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Issue

Vol. 17 No. 10: October 2023

Section

Original Articles

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