A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid

Yiyun Ni; Bin Liu; Weizhen Zhang; Shengwen Shi; Jianchao Deng

doi:10.3855/jidc.18541

A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid

Authors

Yiyun Ni The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China https://orcid.org/0000-0002-4337-6353
Bin Liu The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China https://orcid.org/0000-0002-2224-0262
Weizhen Zhang The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China https://orcid.org/0000-0003-0342-7555
Shengwen Shi The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China
Jianchao Deng The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan Province, 425000, China https://orcid.org/0000-0002-1233-0344

DOI:

https://doi.org/10.3855/jidc.18541

Keywords:

HFRS, ferritin, vitamin B12, folic acid

Abstract

Introduction: Hemorrhagic fever with renal syndrome (HFRS) is a globally prevalent infectious disease caused by the hantavirus in rodents.

Case study: This report describes a case of a 36-year-old male presenting with elevated ferritin, vitamin B₁₂, and folic acid deficiency during the early onset phase of HFRS. Despite normal renal function at admission, the patient exhibited persistent fever and thrombocytopenia, leading to a potential misdiagnosis of an atypical HFRS presentation. Abnormal serum levels of ferritin, vitamin B₁₂, and folic acid served as early indicators of renal dysfunction in patients with HRFS. The patient's condition improved rapidly with a combination of vitamin B₆, methyl cobalamin, and folic acid, as evidenced by a subsequent decrease in the ferritin levels, from 3000 to 600 ng/mL, on days 4 and 24, respectively, and an increase in the vitamin B₁₂ and folic acid levels to 200 pg/mL and 36.7 ng/mL, separately.

Conclusions: These findings suggest that ferritin, vitamin B₁₂, and folic acid have the potential to serve as biomarkers for HFRS and play a predictive role in the diagnosis and treatment of the disease.

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Published

2024-01-31

How to Cite

Ni Y, Liu B, Zhang W, Shi S, Deng J (2024) A case of hemorrhagic fever with renal syndrome and abnormal serum levels of ferritin, vitamin B12, and folic acid. J Infect Dev Ctries 18:168–171. doi: 10.3855/jidc.18541

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Issue

Vol. 18 No. 01: January 2024

Section

Case Reports

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