Does organophosphorus poisoning increase the risk of staphylococcal ventilator associated pneumonia? – a retrospective study

Avijit Chauhan; Hariswar Pari; Radha Sugumaran; Venkateswaran Ramanathan

doi:10.3855/jidc.18125

Does organophosphorus poisoning increase the risk of staphylococcal ventilator associated pneumonia? – a retrospective study

Authors

Avijit Chauhan Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India https://orcid.org/0000-0003-1937-737X
Hariswar Pari Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
Radha Sugumaran Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
Venkateswaran Ramanathan Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India https://orcid.org/0000-0002-1602-5785

DOI:

https://doi.org/10.3855/jidc.18125

Keywords:

organophosphorus poisoning, Staphylococcus aureus, ventilator associated pneumonia, MRSA, developing countries

Abstract

Introduction: The aim of this study was to determine the clinical predictors of staphylococcal ventilator-associated pneumonia (VAP) and to compare the outcomes of staphylococcal VAP with non-staphylococcal VAP.

Methodology: A retrospective observational study was conducted among adult patients admitted to the medical intensive care unit (MICU) in a tertiary care hospital in India from January 2017 to December 2019. The patients were grouped based on their diagnosis into staphylococcal and non-staphylococcal VAP, and the baseline characteristics, clinical parameters, co-morbidities, and outcome parameters were compared.

Results: Out of 2129 MICU admissions, 456 patients with microbiologically confirmed VAP were included, of which 69 (15.1%) had staphylococcal VAP, and the remaining 387 (84.9%) had non-staphylococcal VAP. Organophosphorus (OP) poisoning was identified as an independent predictor of staphylococcal VAP (odds ratio: 2.57; 95% CI: 1.4 to 4.73). The median duration of mechanical ventilation before VAP diagnosis was less in the staphylococcal VAP group (4 vs. 5 days; p = 0.004). The staphylococcal group also showed a better in-hospital outcome.

Conclusions: OP poisoning was an independent predictor of staphylococcal VAP. Staphylococcal VAP was diagnosed earlier in patients than non-staphylococcal VAP. Screening for nasal carriage for Staphylococcus, especially in patients with OP poisoning at the time of MICU admission, may help guide antibiotic therapy.

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Published

2024-02-29

How to Cite

Chauhan A, Pari H, Sugumaran R, Ramanathan V (2024) Does organophosphorus poisoning increase the risk of staphylococcal ventilator associated pneumonia? – a retrospective study. J Infect Dev Ctries 18:277–284. doi: 10.3855/jidc.18125

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Issue

Vol. 18 No. 02: February 2024

Section

Original Articles

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