Comparison of efficacies of different treatments for nontuberculous mycobacterial pulmonary disease in Anhui Province, China

Zhaoyu Zha; Long Gao; Dongping Wang; Dongfang Xu; Yanyan Liu; Yi Liu; Shengsheng Liu; Jiabin Li; Wenhong Lin

doi:10.3855/jidc.18604

Comparison of efficacies of different treatments for nontuberculous mycobacterial pulmonary disease in Anhui Province, China

Authors

Zhaoyu Zha Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui, China https://orcid.org/0000-0001-5857-6596
Long Gao Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Dongping Wang Department of Microbiology, Anhui Chest Hospital, Hefei, Anhui, China
Dongfang Xu Department of Microbiology, Anhui Chest Hospital, Hefei, Anhui, China
Yanyan Liu Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Yi Liu Department of Bacteriology and Immunology, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital, Capital Medical University, Tongzhou District, Beijing, China
Shengsheng Liu Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui, China https://orcid.org/0000-0002-4154-9003
Jiabin Li Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Wenhong Lin Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui, China

DOI:

https://doi.org/10.3855/jidc.18604

Keywords:

nontuberculous mycobacterium, epidemiology, therapeutic

Abstract

Introduction: Although nontuberculous mycobacterial (NTM) infection is a common cause of pulmonary disease worldwide, few studies have focused on epidemiological and therapeutic factors related to NTM cases in Anhui Province, China. This retrospective study aimed to identify aetiological and clinical factors, and treatment outcomes of patients with NTM pulmonary disease (NTMPD) in Anhui.

Methodology: Retrospective clinical data obtained from medical records of NTMPD patients seeking care at Anhui Chest Hospital from July 2019 to June 2022 were analyzed. Treatment outcomes were compared between two patient groups: one receiving a standardised NTM treatment regimen and the other receiving precision treatment regimens.

Results: Genotypic analysis of 672 clinical NTMPD-associated isolates revealed that most were Mycobacterium intracellulare, while drug-susceptibility test results demonstrated diverse antibiotic resistance profiles for these isolates. Cough was the most common symptom for 101 NTMPD patients. After patients of both groups received treatment, symptoms improved, sputum culture conversion was observed for some patients, imaging findings stabilised; however, no statistically significant intergroup differences in treatment outcomes were found.

Conclusions: In this study, M. intracellulare was the predominant NTM species identified in isolates obtained from NTMPD patients. Drug resistance profiles of our patient isolates were complex, highlighting the need for administration of timely, more effective, standardised treatments for patients with NTMPD in Anhui Province, China.

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Published

2024-05-30

How to Cite

Zha Z, Gao L, Wang D, Xu D, Liu Y, Liu Y, Liu S, Li J, Lin W (2024) Comparison of efficacies of different treatments for nontuberculous mycobacterial pulmonary disease in Anhui Province, China. J Infect Dev Ctries 18:751–760. doi: 10.3855/jidc.18604

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Issue

Vol. 18 No. 05: May 2024

Section

Original Articles

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