Clinical features and risk factors for mortality in patients with Klebsiella pneumoniae bloodstream infections

Panpan Xu; Xijiang Zhang; Qingqing Chen; Qin Si; Xinhua Luo; Chuming Zhang; Zongguang He; Ronghai Lin; Cheng Zheng

doi:10.3855/jidc.18649

Clinical features and risk factors for mortality in patients with Klebsiella pneumoniae bloodstream infections

Authors

Panpan Xu Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Xijiang Zhang Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Qingqing Chen Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang 318050, China
Qin Si Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Xinhua Luo Department of Clinical Microbiology Laboratory, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Chuming Zhang Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Zongguang He Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Ronghai Lin Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China
Cheng Zheng Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, China

DOI:

https://doi.org/10.3855/jidc.18649

Keywords:

Klebsiella pneumoniae, mortality, bloodstream infections, clinical features, risk factor

Abstract

Introduction: Concern about Klebsiella pneumoniae (K. pneumoniae) bloodstream infections (KP-BSIs) is widespread because of their high incidence and lethality. The aim of this study was to investigate the clinical features of, and risk factors for mortality caused by KP-BSIs.

Methodology: This was a single-center retrospective observational study performed between 1 January 2019 and 31 December 2021, at a tertiary hospital. All patients with KP-BSIs were enrolled and their clinical data were retrieved from electronic medical records.

Results: A total of 145 patients were included (121 in the survival group and 24 in the non-survival group). There was a higher proportion of lower respiratory tract infections in the non-survival group than in the survival group (33.3% vs. 12.4%) (p < 0.05). There was a higher proportion of multi drug resistant (MDR) strains of K. pneumoniae in the non-survival group than in the survival group (41.7% vs. 16.5%) (p < 0.05). Multivariate analysis revealed that sequential organ failure assessment (SOFA) score > 6.5 (OR, 13.71; 95% CI, 1.05–179.84), admission to the intensive care unit (ICU) (OR, 2.27; 95% CI, 0.26–19.61) and gastrointestinal bleeding (OR, 19.97; 95% CI, 1.11–361.02) were independent risk factors for death in patients with KP-BSIs.

Conclusions: Among all KP-BSIs, a high proportion of K. pneumoniae originated from lower respiratory tract infections, and a high proportion of K. pneumoniae were MDR; however, mortality was not influenced. SOFA score > 6.5, admission to the ICU, and gastrointestinal bleeding were independent risk factors for death in patients with KP-BSI.

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Published

2024-06-30

How to Cite

Xu P, Zhang X, Chen Q, Si Q, Luo X, Zhang C, He Z, Lin R, Zheng C (2024) Clinical features and risk factors for mortality in patients with Klebsiella pneumoniae bloodstream infections. J Infect Dev Ctries 18:843–850. doi: 10.3855/jidc.18649

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Issue

Vol. 18 No. 06: June 2024

Section

Emerging Problems in Infectious Diseases

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