Post-mortem diagnosis of human rabies in SARS-CoV-2 coinfected patient with minimally invasive autopsy in northeastern Brazil

Authors

  • Luis Arthur BG Farias Department of Infectious Diseases of Hospital das Clínicas and Laboratório de Investigação Médica – LIM 49, University of São Paulo, São Paulo, Brazil https://orcid.org/0000-0002-8978-9903
  • Marcos M Sousa São José Hospital for Infectious Diseases, Fortaleza, Brazil
  • Ruth Maria O de Araujo São José Hospital for Infectious Diseases, Fortaleza, Brazil https://orcid.org/0000-0002-3023-3601
  • Kelma M Maia São José Hospital for Infectious Diseases, Fortaleza, Brazil
  • Madalena Q de Azevedo São José Hospital for Infectious Diseases, Fortaleza, Brazil
  • Nancy C de Oliveira Caetano São José Hospital for Infectious Diseases, Fortaleza, Brazil https://orcid.org/0000-0002-0924-9932
  • Karene F Cavalcante Central Public Health Laboratory (LACEN), Fortaleza, Brazil
  • Liana P Mello Central Public Health Laboratory (LACEN), Fortaleza, Brazil
  • Larissa Leao F de Sousa Central Public Health Laboratory (LACEN), Fortaleza, Brazil
  • Sami de Andrade C Gadelha Death Verification Service, Fortaleza, Brazil https://orcid.org/0000-0001-5214-6771
  • Deborah N de Melo Death Verification Service, Fortaleza, Brazil
  • Ana Karine B Carneiro Secretary of Health of the State of Ceará (SESA), Fortaleza, Brazil
  • Tânia Mara S Coelho Secretary of Health of the State of Ceará (SESA), Fortaleza, Brazil
  • Antônio Silva L Neto Secretary of Health of the State of Ceará (SESA), Fortaleza, Brazil
  • Francisco Edson B Abreu São José Hospital for Infectious Diseases, Fortaleza, Brazil
  • Kellyn Kessiene de S Cavalcante Secretary of Health of the State of Ceará (SESA), Fortaleza, Brazil
  • Silvia F Costa Department of Infectious Diseases of Hospital das Clínicas and Laboratório de Investigação Médica – LIM 49, University of São Paulo, São Paulo, Brazil
  • Luciano P de Goes Cavalcanti Secretary of Health of the State of Ceará (SESA), Fortaleza, Brazil
  • Lauro V Perdigão Neto Department of Infectious Diseases of Hospital das Clínicas and Laboratório de Investigação Médica – LIM 49, University of São Paulo, São Paulo, Brazil

DOI:

https://doi.org/10.3855/jidc.19427

Keywords:

human rabies, marmoset, autopsy, COVID-19

Abstract

Introduction: Human rabies (HR) is a lethal zoonotic disease caused by lyssaviruses with increase in the number of cases post-coronavirus disease 2019 (COVID-19) pandemic.

Methodology: We report a case of human rabies in a patient from a rural area of Ceará, northeastern Brazil in 2023, who was bitten by a white-tufted-ear marmoset (Callithrix jacchus jacchus). The patient was co-infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and was diagnosed by minimally invasive autopsy (MIA).

Results: MIA offers many advantages related to biosafety, and speed of sample acquisition; and markedly reduces disfigurement of the body compared with complete autopsy. It is a great alternative in COVID-19 patients.

Conclusions: New methods such as MIA are a promising tool for diagnosis, and have the potential to improve family cooperation and support rabies surveillance.

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Published

2024-07-29

How to Cite

1.
Farias LAB, Sousa MM, de Araujo RMO, Maia KM, de Azevedo MQ, de Oliveira Caetano NC, Cavalcante KF, Mello LP, de Sousa LLF, Gadelha S de AC, de Melo DN, Carneiro AKB, Coelho TMS, Neto ASL, Abreu FEB, Cavalcante KK de S, Costa SF, de Goes Cavalcanti LP, Perdigão Neto LV (2024) Post-mortem diagnosis of human rabies in SARS-CoV-2 coinfected patient with minimally invasive autopsy in northeastern Brazil. J Infect Dev Ctries 18:982–986. doi: 10.3855/jidc.19427

Issue

Vol. 18 No. 07: July 2024

Section

Coronavirus Pandemic

License

Copyright (c) 2024 Luís Arthur Brasil Gadelha Farias, Marcos Maciel Sousa, Ruth Maria Oliveira de Araujo, Kelma Maria Maia, Madalena Quinto de Azevedo, Nancy Costa de Oliveira Caetano, Karene Ferreira Cavalcante, Liana Perdigão Mello, Larissa Leão Ferrer de Sousa, Sami de Andrade Cordeiro Gadelha, Deborah Nunes de Melo, Ana Karine Borges Carneiro, Tania Mara Silva Coelho, Antônio Silva Lima Neto, Francisco Edson Buhamra Abreu, Kellyn Kessiene de Sousa Cavalcante, Silvia Figueiredo Costa, Luciano Pamplona de Góes Cavalcanti, Lauro Vieira Perdigão Neto

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