Association of OAS1 and MxA variants with COVID-19 in Pakistani patients

Naila Shaikh; Feriha Fatima Khidri; Hina Shaikh; Amber Mahmood; Atif Sitwat Hayat; Yar Muhammad Waryah; Tarachand Devrajani; Ikram Din Ujjan; Ali Muhammad Waryah

doi:10.3855/jidc.19697

Association of OAS1 and MxA variants with COVID-19 in Pakistani patients

Authors

Naila Shaikh Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Feriha Fatima Khidri Department of Biochemistry, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan https://orcid.org/0000-0003-0319-8772
Hina Shaikh Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Amber Mahmood Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Atif Sitwat Hayat Department of Medicine, Roshan Suleman Medical College, Tando Adam, Pakistan
Yar Muhammad Waryah Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Tarachand Devrajani Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan https://orcid.org/0000-0002-9666-8181
Ikram Din Ujjan Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Ali Muhammad Waryah Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI:

https://doi.org/10.3855/jidc.19697

Keywords:

COVID-19, gene, MxA, OAS1, Pakistani, variant

Abstract

Introduction: Coronaviruses, a family of enveloped RNA viruses, have been implicated in various clinical disorders including coronavirus disease 2019 (COVID-19). Host genetic factors, including the OAS1 and MxA gene variants may have a role in determining susceptibility to viral infections. Understanding the genetic factors involved in unraveling COVID-19`s diverse clinical outcomes is critical for disease management. This study investigated the impact of OAS1 rs2660 and MxA rs2071430 genotypes on COVID-19 susceptibility and severity among Pakistani patients.

Methodology: This was a comparative cross-sectional study. Fifty patients diagnosed with COVID-19 and 50 controls were recruited and genotyped for the selected gene variants.

Results: The OAS1 gene rs2660 exhibited an association with COVID-19 susceptibility in various genetic models. The risk decreased with AG genotype (OR = 0.23, 95% CI = 0.09-0.58; p = 0.0011) compared to GG in codominant models. In dominant (OR = 0.35, 95% CI = 0.15-0.81; p = 0.013) and overdominant (OR = 0.21, 95% CI = 0.08-0.53; p = 0.0005) models, the single nucleotide variant (SNV) decreased COVID-19 susceptibility risk. There was no association of OAS1 rs2660 genotypes with COVID-19 severity. We did not find a significant association between MxA rs2071430 variant and COVID-19 susceptibility.

Conclusions: OAS1 rs2660 AG genotype showed decreased risk of COVID-19 susceptibility among Pakistani patients. This study provides insight into the role of the OAS1 and MxA variants in COVID-19. This finding could aid researchers in understanding genetic susceptibility and severity in COVID-19 by identifying at-risk individuals and determining the optimal treatment.

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Published

2024-09-30

How to Cite

Shaikh N, Khidri FF, Shaikh H, Mahmood A, Hayat AS, Waryah YM, Devrajani T, Ujjan ID, Waryah AM (2024) Association of OAS1 and MxA variants with COVID-19 in Pakistani patients. J Infect Dev Ctries 18:S147-S152. doi: 10.3855/jidc.19697

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Issue

Vol. 18 No. 09.1: September 2024 - SUPPLEMENT

Section

Coronavirus Pandemic

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