Expression and clinical significance of IL-8 and Wnt2 in Helicobacter pylori-infected gastric cancer patients

Li Lin; Ruiyu Tao; Yonggang Cai; Qiang Zhao; Ke Yang; Wenjuan Yang; Fengxia Guo

doi:10.3855/jidc.20205

Expression and clinical significance of IL-8 and Wnt2 in Helicobacter pylori-infected gastric cancer patients

Authors

Li Lin Department of Hematology, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China https://orcid.org/0000-0001-5735-2400
Ruiyu Tao Department of General Surgery, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China
Yonggang Cai Department of Hematology, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China
Qiang Zhao Department of Hematology, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China
Ke Yang Department of Hematology, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China
Wenjuan Yang Department of Hematology, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China
Fengxia Guo Department of Hematology, Gansu Provincial Maternity and Child-Care Hospital (Gansu Province Central Hospital), Lanzhou 730070, China

DOI:

https://doi.org/10.3855/jidc.20205

Keywords:

gastric cancer, Helicobacter pylori, interleukin-8, Wnt2, prognosis

Abstract

Introduction: We assessed the expression levels of interleukin-8 (IL-8) and Wnt2 in Helicobacter pylori-infected gastric cancer (GC) patients, and investigated the association of these proteins with prognosis.

Methodology: Seventy-two GC patients, including 40 cases with H. pylori infection and 32 cases without H. pylori infection, were enrolled. Tumor and para-tumor normal tissues were collected. H. pylori infection was determined using the rapid urease test and Warthin-Starry silver staining. The expressions of IL-8 and Wnt2 were assessed using immunohistochemistry. The association between H. pylori infection, IL-8, Wnt2, and pathological and clinical data was analyzed. The relationship between H. pylori, IL-8, Wnt2, and prognosis was assessed using survival curves and regression analyses.

Results: The expression levels of IL-8 and Wnt2 in GC tissue significantly exceeded that in normal mucosa. The expression levels of IL-8 and Wnt2 were significantly higher in patients with H. pylori infection, than in those without H. pylori infection; and a positive correlation was observed between IL-8 and Wnt2 expressions. The positivity rate of IL-8 and Wnt2 in early-stage GC without lymph node metastasis markedly differed from that in advanced-stage GC with lymph node metastasis. Additionally, the survival rate of GC patients with positive IL-8 and Wnt2 expressions was significantly lower than in patients without such expression patterns. Clinical stage and Wnt2 were identified as independent prognostic factors of GC.

Conclusions: IL-8 and Wnt2 were prognostic indicators for GC. H. pylori and IL-8 were not independent prognostic factors, whereas Wnt2 could independently serve as a prognostic factor for GC.

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Published

2024-10-31

How to Cite

Lin L, Tao R, Cai Y, Zhao Q, Yang K, Yang W, Guo F (2024) Expression and clinical significance of IL-8 and Wnt2 in Helicobacter pylori-infected gastric cancer patients. J Infect Dev Ctries 18:1512–1521. doi: 10.3855/jidc.20205

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Issue

Vol. 18 No. 10: October 2024

Section

Original Articles

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