Profile of co-occurring or secondary infections among COVID-19 patients with HBOT: a single-center retrospective study

Authors

  • Peixia Yu Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Hairu Wang Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Ziyang Li Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Junyan Zhang Department of Clinical Epidemiology and Evidence-based Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China https://orcid.org/0000-0002-7890-3707
  • Shuang Wei Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • Zhifeng Xue Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Bozheng Zhang Emory University College of Arts and Sciences, Atlanta, GA, USA https://orcid.org/0000-0003-1199-2175
  • Qi Mei Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China
  • Zhengtao Wang Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Yani Zhao Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Qing Niu Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China
  • Pingzhi Wang Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China

DOI:

https://doi.org/10.3855/jidc.20460

Keywords:

coronavirus disease-19 (COVID-19), hyperbaric oxygen therapy (HBOT), co-occurring infections, secondary infections, multidrug-resistant organisms (MDROs)

Abstract

Introduction: This study was designed to describe the profile of co-occurring or secondary infections in hospitalized coronavirus disease 2019 (COVID-19) patients undergoing hyperbaric oxygen therapy (HBOT) and those without.

Methodology: Out of 716 COVID-19 patients, 79 cases of co-occurring or secondary infections were included. These patients were categorized into two groups based on their usage of HBOT. The basic information and laboratory examinations, especially pathogen-related results were collected from the medical records. The rate of co-occurring or secondary infections, distribution of pathogens, infection sites, and results of antimicrobial susceptibility testing were analyzed.

Results: Among the 79 COVID-19 patients examined, there were 73 cases of infections, including 58 co-occurring infections, 14 secondary infections, and 1 mixed infection in the non-HBOT group. There were 6 cases with co-occurring or secondary infections in the HBOT group. Influenza virus was predominant in the co-occurring or secondary infections of COVID-19 patients, but it was not detected in patients undergoing HBOT. Klebsiella pneumoniae, Corynebacterium striatum, and Acinetobacter baumannii were the main strains isolated among patients with HBOT. The multidrug-resistant organisms (MDROs) strains of Escherichia coli, Klebsiella aerogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecium were detected from COVID-19 patients treated with HBOT.

Conclusions: This study described the profile of in-hospital co-occurring or secondary infections in COVID-19 patients from North China. Management of the co-occurring or secondary infections, especially MDROs infections treated with HBOT, including but not limited to COVID-19, should be strengthened.

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Published

2024-11-30

How to Cite

1.
Yu P, Wang H, Li Z, Zhang J, Wei S, Xue Z, Zhang B, Mei Q, Wang Z, Zhao Y, Niu Q, Wang P (2024) Profile of co-occurring or secondary infections among COVID-19 patients with HBOT: a single-center retrospective study. J Infect Dev Ctries 18:1663–1670. doi: 10.3855/jidc.20460

Issue

Vol. 18 No. 11: November 2024

Section

Coronavirus Pandemic

License

Copyright (c) 2024 Peixia Yu, Hairu Wang, Ziyang Li, Junyan Zhang, Shuang Wei, Zhifeng Xue, Bozheng Zhang, Qi Mei, Zhengtao Wang, Yani Zhao, Qing Niu, Pingzhi Wang

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