Antimicrobial consumption and resistance in a tertiary care hospital in Brazil: a 7-year time series

Amanda F Medeiros; Caryne M Bertollo; Bárbara CD Faria; Claudmeire DC Almeida; Edna MM Leite; Laura R Vieira; Ana FF Souza; Mauro HNG Abreu; Renan P Souza; Maria AP Martins

doi:10.3855/jidc.19019

Antimicrobial consumption and resistance in a tertiary care hospital in Brazil: a 7-year time series

Authors

Amanda F Medeiros Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0002-6747-6172
Caryne M Bertollo Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0002-4115-559X
Bárbara CD Faria Faculdade de Medicina da Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0003-3928-3573
Claudmeire DC Almeida Hospital das Clínicas da Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0003-2109-116X
Edna MM Leite Hospital Risoleta Tolentino Neves, Universidade Federal de Minas Gerais, Brazil
Laura R Vieira Hospital Risoleta Tolentino Neves, Universidade Federal de Minas Gerais, Brazil https://orcid.org/0009-0009-8669-1714
Ana FF Souza Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0002-6672-4816
Mauro HNG Abreu Departamento de Odontologia Social e Preventiva, Faculdade de Odontologia da Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0001-8794-5725
Renan P Souza Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Brazil https://orcid.org/0000-0002-9479-4432
Maria AP Martins Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil

DOI:

https://doi.org/10.3855/jidc.19019

Keywords:

antimicrobial stewardship, drug utilization review, drug resistance, outcome assessment, pharmacoepidemiology, COVID-19

Abstract

Introduction: Antimicrobial resistance (AMR) is a major public health challenge globally. This study aimed to analyze the antibacterial consumption (ATBc), and the incidence of multidrug-resistant organisms (MDRO), focusing on pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE group), in a Brazilian tertiary care hospital.

Methodology: The ATBc was measured by defined daily doses (DDD) calculated per 1000 patient days. The incidence of MDRO was collected from the hospital infection control committee specialized reports. Changes in ATBc and MDRO incidence over time were explained by the compound annual growth rate (CAGR) represented by the average yearly change as a proportion (%) of consumption in the starting year. This was a time series study using data collected retrospectively from January 2015 to December 2021.

Results: There was an increase in consumption of daptomycin and linezolid during the study period (39.4% and 27.7%, respectively), followed by polymyxins (9.8%). The MDRO of the ESKAPE group with the highest variation in the period were Staphylococcus spp (29.2%), Enterococcus spp (27.8%), and Acinetobacter spp (18.4%). Other MDROs, outside the ESKAPE group, such as Providencia sp (51.2%) and Clostridioides dificille (37.7%) had significant variation.

Conclusions: The coronavirus disease 2019 (COVID-19) pandemic may have reinforced the deterioration of the scenario of accelerating AMR increase. This warrants investigations of further surveillance data to assess the impact of the pandemic on AMR epidemiological trends.

Downloads

Published

2024-12-31

How to Cite

Medeiros AF, Bertollo CM, Faria BC, Almeida CD, Leite EM, Vieira LR, Souza AF, Abreu MH, Souza RP, Martins MA (2024) Antimicrobial consumption and resistance in a tertiary care hospital in Brazil: a 7-year time series. J Infect Dev Ctries 18:S344-S352. doi: 10.3855/jidc.19019

Download Citation

Endnote/Zotero/Mendeley (RIS)

Issue

Vol. 18 No. 12.1: December 2024 -- SUPPLEMENT

Section

Coronavirus Pandemic

License

Copyright (c) 2024 Amanda Fonseca Medeiros, Caryne Margotto Bertollo, Bárbara Caroline Dias Faria, Claudmeire Dias Carneiro de Almeida, Edna Marilea Meireles Leite, Laura Rodrigues Vieira, Ana Flávia Figueiró de Souza, Mauro Henrique Nogueira Guimarães de Abreu, Renan Pedra de Souza, Maria Auxiliadora Parreiras Martins

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).