Wide spread of OXA-48-producing Enterobacteriaceae in Algerian hospitals: A four years’ study

Nadjet Aggoune; Hassiba Tali Maamar; Farida Assaous; Badia Guettou; Rym Laliam; Nabila Benamrouche; Ali Zerouki; Malek Naim; Kheira Rahal

doi:10.3855/jidc.9692

Wide spread of OXA-48-producing Enterobacteriaceae in Algerian hospitals: A four years’ study

Authors

Nadjet Aggoune Hôpital central de l’armée Mohammed Seghir Nekkache, Alger, Algérie
Hassiba Tali Maamar Institut Pasteur d’Algérie Alger, Algérie
Farida Assaous Institut Pasteur d’Algérie Alger, Algérie
Badia Guettou Institut Pasteur d’Algérie Alger, Algérie
Rym Laliam Institut Pasteur d’Algérie Alger, Algérie
Nabila Benamrouche Institut Pasteur d’Algérie Alger, Algérie
Ali Zerouki Hôpital central de l’armée Mohammed Seghir Nekkache, Alger, Algérie
Malek Naim Hôpital central de l’armée Mohammed Seghir Nekkache, Alger, Algérie
Kheira Rahal Institut Pasteur d’Algérie Alger, Algérie

DOI:

https://doi.org/10.3855/jidc.9692

Keywords:

Carbapenemase, OXA-48, NDM, Klebsiella pneumoniae, sequence type, Algeria

Abstract

Introduction: The aim of this study was to investigate the presence of carbapenemase-producing Enterobacteriaceae (CPE) in Algerian hospitals and to characterize the molecular types of carbapenemases found.

Methodology: During a four years study lasting between 2012 and 2015, 81 strains of Enterobacteriaceae with reduced susceptibility to carbapenems were collected from different hospitals. Carbapenemase genes were detected by PCR. Multi locus sequence typing was used to study genetic relationships between carbapenemase- producing Klebsiella pneumoniae isolates.

Results: Among 56 confirmed CPE, bla_OXA-48was detected in 98.21% of isolates. Two isolates co-expressed NDM, and a single one was only an NDM producer. The strains displayed various susceptibility patterns to antibiotics with variable levels of resistance to carbapenems. Multilocus sequence typing (MLST) revealed the presence of multiple sequence types in circulation.

Conclusions: This report highlights the wide distribution of several clones of OXA-48-producing Enterobacteriaceae in Algeria. Urgent action should be taken to avoid epidemic situations.

Downloads

Published

2018-11-30

How to Cite

Aggoune N, Tali Maamar H, Assaous F, Guettou B, Laliam R, Benamrouche N, Zerouki A, Naim M, Rahal K (2018) Wide spread of OXA-48-producing Enterobacteriaceae in Algerian hospitals: A four years’ study. J Infect Dev Ctries 12:1039–1044. doi: 10.3855/jidc.9692

Download Citation

Endnote/Zotero/Mendeley (RIS)

Issue

Vol. 12 No. 11: November 2018

Section

Brief Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).