Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam

  • Vu Quoc Huy Nguyen Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Viet Quynh Tram Ngo Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Minh Tam Le Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Hoang Bach Nguyen Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Van Bao Thang Phan Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Quang Vinh Truong Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Ngoc Thanh Cao Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
  • Piero Cappuccinelli Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam
Keywords: HPV, genital tract infection, real-time PCR, Reverse dot-blot

Abstract

Introduction: This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam.

Methodology: Cross-sectional study on 1,034 women of reproductive age from 11 communes/wards of three districts representing three different geographic areas of Thua Thien Hue Province, Vietnam. The hospital-based group included 102 women with cervicitis and/or abnormal Pap smear result coming to Hue University Hospital. Extracting DNA from cervical samples, performing the real-time PCR for detecting HPV and the reverse dot-blot assay for HPV typing in HPV positive cases.

Results: In community, HPV prevalence was 0.9%. Mean-age of HPV positive group was 37.9 ± 6.2 years. The detected low-risk types were 6 and 11; high-risk types include 16, 18, 33, 45, 52, and 58. Single-type infection was found in 66.7% of cases. In hospital-based group, 41.2% of women have been infected with HPV, 6 different HPV types were detected. HPV18 was the most frequent high-risk type (33.3%), followed by HPV16 (15.1%); HPV6 was the most frequent among low-risk HPV types (31.2%). Single-type infection rate was 33,3%; 2 and 3 types co-infections were 28,6% and 38.1%, respectively.

Conclusions: Routine screening of high-risk HPV infection in women with symptomatic gynecologic infection and/or abnormal Pap smear appears to be benefit in early detection and prevention of cervical cancer, due to the high incidence of HPV infection.

Author Biographies

Vu Quoc Huy Nguyen, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Obstetrics and Gynecology

Viet Quynh Tram Ngo, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Microbiology

Minh Tam Le, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Obstetrics and Gynecology

Hoang Bach Nguyen, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Microbiology

Van Bao Thang Phan, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Microbiology

Quang Vinh Truong, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Obstetrics and Gynecology

Ngoc Thanh Cao, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Department of Obstetrics and Gynecology

Piero Cappuccinelli, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam

Carlo Urbani Center

Published
2018-07-31
How to Cite
1.
Nguyen VQH, Ngo VQT, Le MT, Nguyen HB, Phan VBT, Truong QV, Cao NT, Cappuccinelli P (2018) Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam. J Infect Dev Ctries 12:568-572. doi: 10.3855/jidc.10297
Section
Original Articles