Liver involvement in the process of acute respiratory infections in pediatric patients

  • Nune Baghdasaryan Department of Pediatrics # 1,Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • Gohar Ayvazyan Department of Pediatrics # 1,Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • Murad Grigoryan Department of Pediatrics # 1,Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • Lilit Avetisyan Department of Pediatrics # 1,Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • Olya Asatryan Department of Pediatrics # 1,Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • Nane Mnatsakanyan Department of Pediatrics # 1,Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • Anush Perikhanyan Medical Affairs Department,FMD Contract Research Organization, Yerevan , Armenia
Keywords: Ornithine carbamoyltransferase (OCT), liver dysfunction, liver panel, noninvasive indicators of liver damage, acute respiratory infection (ARI)

Abstract

Introduction: We aimed to investigate the prevalence of liver involvement in pediatric patients with ARI using both routine tests of hepatic panel, and ornithine carbamoyltransferase (OCT) to identify the most sensitive indicators of early hepatic injury.

Methodology: A prospective cohort study of 84 armenian children with ARI was conducted to evaluate the associated liver involvement. The diagnostic variables of interest were the signs of clinical disease severity, and enzymatic profile of the patients.

Results: Serum levels of OCT were increased in 94% of patients versus routine tests of hepatic panel (AST in 41.7%, ALT in 15.5%, etc). Variance analysis by severity groups showed the serum levels of OCT (p < 0.001), ammonia (p < 0.001), phospholipides (p = 0.05), glucose (p = 0.01), TNF-α (p = 0.01), IL-8 (p < 0.001), AST (p < 0.001), and ALP (p < 0.001) were associated with the severity of underlying disease. Moreover, regression analysis revealed the serum activity of OCT (p value < 0.001, OR = 1.27) and ammonia (p value 0.002, OR = 1.1) significantly predict the severity of the disease.

Conclusions: Using more sensitive marker of liver damage can detect more cases of ARI with hepatic manifestations. For evaluation of the liver involvement we are suggesting the testing of serum OCT levels as a more sensitive and specific marker. Pediatric patients with ARI and with higher serum OCT levels have 27% more chance to experience increased disease severity, which can affect on liver state and prolong hospitalization time and cost.

Published
2019-05-16
How to Cite
1.
Baghdasaryan N, Ayvazyan G, Grigoryan M, Avetisyan L, Asatryan O, Mnatsakanyan N, Perikhanyan A (2019) Liver involvement in the process of acute respiratory infections in pediatric patients. J Infect Dev Ctries 13:063S-068S. doi: https://doi.org/10.3855/jidc.10914
Section
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