Evaluation of IL-2, IL-10, IL-4 and ɤ-interferon levels in the oral fluids of patients with hepatitis C, B and HIV

  • Vahe Azatyan Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Lazar Yessayan Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Melanya Shmavonyan Department of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Gayane Melik-Andreasyan National Center of Disease Control and Prevention, The Ministry of Health of Republic of Armenia
  • Anush Perikhanyan Medical Affairs Department, FMD Contract Research Organization, Yerevan, Armenia
  • Kristina Porkshenyan Nork Clinical Infectious Hospital CJSC, Yerevan, Armenia
Keywords: Oral fluid, cytokines, HIV, HCV, HBV

Abstract

Introduction: Oral fluid cytokine levels can vary considerably during the onset of Inflammatory Periodontitis (IP) especially in people with hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Aim of our study was to evaluate levels of oral cytokines during the onset of IP among HCV, HBV and HIV negative and positive individuals in order to evaluate local immunity state during these infections.

Methodology: This was a case control study with 3 groups of virally infected individuals and control group. All had IP including control group.

Results: 45 patients (51.7%) had HCV, 18 (20.7%) HBV and 24 (27.6%) HIV. For IL-2 we received significant difference for all groups compared with control -2.83; HBV-31.1 (p < 0.001), HCV-25.99 (p < 0.001) and HIV-24.57 (p < 0.001). For IL-10 significant difference was observed between control -0.94 and HCV-3.63 (p = 0.027), HBV-8.38 (15.51) groups (p < 0.001). IL-4 was significantly higher in control group 14.29 compared to HCV 0.2 (p < 0.001) and HIV 0.21 (p = 0.037) group. The adjusted analysis where we consider age as possible confounder revealed that only IL-2 significantly differs for all groups compared with control group: control vs HCV (p = 0.001); control vs HBV (p = 0.024); control vs HIV (p = 0.004).

Conclusions: Evidence for significant differences when comparing oral fluid cytokines of individuals with HCV, HBV and HIV with non-viral individuals was more obvious for IL-2. IL-2 levels were significantly higher in all 3 groups vs non-viral group even when age is confounder.

Published
2019-05-16
How to Cite
1.
Azatyan V, Yessayan L, Shmavonyan M, Melik-Andreasyan G, Perikhanyan A, Porkshenyan K (2019) Evaluation of IL-2, IL-10, IL-4 and ɤ-interferon levels in the oral fluids of patients with hepatitis C, B and HIV. J Infect Dev Ctries 13:069S-074S. doi: https://doi.org/10.3855/jidc.10919
Section
The Armenian SORT IT Course