In vitro activity of essential oils against Pseudomonas aeruginosa isolated from infected hip implants

Veronica Amorese; Matthew Donadu; Donatella Usai; Angelino Sanna; Fabio Milia; Francesco Pisanu; Paola Molicotti; Stefania Zanetti; Carlo Doria

doi:10.3855/jidc.10988

In vitro activity of essential oils against Pseudomonas aeruginosa isolated from infected hip implants

Authors

Veronica Amorese University of Sassari, Sassari, Italy
Matthew Donadu University of Sassari, Sassari, Italy https://orcid.org/0000-0001-7681-6194
Donatella Usai University of Sassari, Sassari, Italy
Angelino Sanna University of Sassari, Sassari, Italy
Fabio Milia University of Sassari, Sassari, Italy
Francesco Pisanu University of Sassari, Sassari, Italy
Paola Molicotti University of Sassari, Sassari, Italy
Stefania Zanetti University of Sassari, Sassari, Italy
Carlo Doria University of Sassari, Sassari, Italy

DOI:

https://doi.org/10.3855/jidc.10988

Keywords:

Antimicrobials, biopharmaceuticals, hip implants, infection, Pseudomonas spp

Abstract

Introduction: Essential oils have been used since ancient times and are known for their anti-inflammatory, anti-depressive, antiseptic, antifungal and antimicrobial properties.

Methodology: in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris–red thyme geraniol was tested against 16 multidrug-resistant P. aeruginosa strains from infected hip implants as well as the “in vitro” cytotoxic activity on normal human Wong-Kilbourne derivative (WKD) cells.

Results: Thymus vulgaris–red thyme geraniol showed lower antimicrobial activity when compared to Melaleuca alternifolia. All tested oils were cytotoxic at concentrations lower than 0.12%.

Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural treatments together with higher concern on environmental issues and natural lifestyle.

Author Biographies

Veronica Amorese, University of Sassari, Sassari, Italy

Department of Surgery, Microsurgery and Medical Sciences, Orthopedic Clinic

Matthew Donadu, University of Sassari, Sassari, Italy

Department of Biomedical Sciences

Donatella Usai, University of Sassari, Sassari, Italy

Department of Biomedical Sciences

Downloads

Published

2018-11-30

How to Cite

Amorese V, Donadu M, Usai D, Sanna A, Milia F, Pisanu F, Molicotti P, Zanetti S, Doria C (2018) In vitro activity of essential oils against Pseudomonas aeruginosa isolated from infected hip implants. J Infect Dev Ctries 12:996–1001. doi: 10.3855/jidc.10988

Download Citation

Endnote/Zotero/Mendeley (RIS)

Issue

Vol. 12 No. 11: November 2018

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).