In vitro activity of essential oils against Pseudomonas aeruginosa isolated from infected hip implants

  • Veronica Amorese University of Sassari, Sassari, Italy
  • Matthew Donadu University of Sassari, Sassari, Italy http://orcid.org/0000-0001-7681-6194
  • Donatella Usai University of Sassari, Sassari, Italy
  • Angelino Sanna University of Sassari, Sassari, Italy
  • Fabio Milia University of Sassari, Sassari, Italy
  • Francesco Pisanu University of Sassari, Sassari, Italy
  • Paola Molicotti University of Sassari, Sassari, Italy
  • Stefania Zanetti University of Sassari, Sassari, Italy
  • Carlo Doria University of Sassari, Sassari, Italy
Keywords: Antimicrobials, biopharmaceuticals, hip implants, infection, Pseudomonas spp

Abstract

Introduction: Essential oils have been used since ancient times and are known for their anti-inflammatory, anti-depressive, antiseptic, antifungal and antimicrobial properties.

Methodology: in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris–red thyme geraniol was tested against 16 multidrug-resistant P. aeruginosa strains from infected hip implants as well as the “in vitro” cytotoxic activity on normal human Wong-Kilbourne derivative (WKD) cells.

Results: Thymus vulgaris–red thyme geraniol showed lower antimicrobial activity when compared to Melaleuca alternifolia. All tested oils were cytotoxic at concentrations lower than 0.12%.

Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural treatments together with higher concern on environmental issues and natural lifestyle.

Author Biographies

Veronica Amorese, University of Sassari, Sassari, Italy

Department of Surgery, Microsurgery and Medical Sciences, Orthopedic Clinic

Matthew Donadu, University of Sassari, Sassari, Italy

Department of Biomedical Sciences

Donatella Usai, University of Sassari, Sassari, Italy

Department of Biomedical Sciences

Published
2018-11-30
How to Cite
1.
Amorese V, Donadu M, Usai D, Sanna A, Milia F, Pisanu F, Molicotti P, Zanetti S, Doria C (2018) In vitro activity of essential oils against Pseudomonas aeruginosa isolated from infected hip implants. J Infect Dev Ctries 12:996-1001. doi: 10.3855/jidc.10988
Section
Original Articles