Enhancement of antimicrobial activity of pump inhibitors associating drugs

  • Donatella Usai Department of Biological Science, University of Sassari, Sassari, Italy
  • Matthew Donadu Department of Biological Science, University of Sassari, Sassari, Italy http://orcid.org/0000-0001-7681-6194
  • Alessandra Bua Department of Biological Science, University of Sassari, Sassari, Italy
  • Paola Molicotti Department of Biological Science, University of Sassari, Sassari, Italy
  • Stefania Zanetti Department of Biological Science, University of Sassari, Sassari, Italy
  • Sandra Piras Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
  • Paola Corona Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
  • Roberta Ibba Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
  • Antonio Carta Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy
Keywords: Bacteria, efflux, resistance

Abstract

Introduction: with the continuous emergence of pathogenic resistance to conventional drugs through efflux pumps, increasing efforts are directed toward discovering efflux inhibitory molecules.

Methodology: in this study three P-glycoprotein (P13CP, P22CP, P34CP) efflux-inhibitors (EIs), belonging to the series of phenoxymethylquinoxalines capable to restore/potentiate the antiproliferative activity of doxorubicin and vincristine against human tumor cell lines and different antibiotics against clinical isolates, were investigated on 10 clinical strains of Candida and 12 clinical and ATCC strains of Gram positive and Gram-negative bacteria.

Results: MFC values of FLC were reduced in all Candida strains by the P22CP and P34CP inhibitors, and in 5/10 fungal strains by the P13CP inhibitor.

Conclusion: novel antibiotics with new modes of action are urgently required to suppress the rise of MDR bacteria. An alternative approach would be to identify molecules that can interfere with the process of efflux.

Published
2019-02-28
How to Cite
1.
Usai D, Donadu M, Bua A, Molicotti P, Zanetti S, Piras S, Corona P, Ibba R, Carta A (2019) Enhancement of antimicrobial activity of pump inhibitors associating drugs. J Infect Dev Ctries 13:162-164. doi: https://doi.org/10.3855/jidc.11102
Section
Brief Original Articles