Evaluation of intestinal parasites in patients with chronic spontaneous urticaria in a territory hospital in Turkey

  • Sedat Vezir Department of Medical Microbiology, Atatürk Chest Disease and Chest Surgery Training and Research Hospital, Health Sciences University, Ankara, Turkey
  • Filiz Kaya Department of Medical Microbiology, Ankara Education and Research Hospital, Health Sciences University, Ankara, Turkey
  • Emine Vezir Department of Pediatric Allergy and Immunology, Ankara Education and Research Hospital, Health Sciences University, Ankara, Turkey
  • Nermin Karaosmanoğlu Department of Dermatology, Ankara Education and Research Hospital, Health Sciences University, Ankara, Turkey
  • Ali Kudret Adiloğlu Department of Medical Microbiology, Ankara Education and Research Hospital, Health Sciences University, Ankara, Turkey
Keywords: Blastocystis, Chronic spontaneous urticaria, Dientamoeba fragilis, intestinal parasite, protozoan infection

Abstract

Introduction: Chronic spontaneous urticaria (CSU) which develops without a known stimulation is defined as the occurrence of spontaneous wheals, angioedema or both for longer than six weeks. Infections, autoimmunity, food intolerance and internal parasitic infections are supposed to be underlying causes of CSU. The aim of this study was to evaluate the intestinal parasites in children and adult patients diagnosed as CSU, to determine the frequency of parasites in chronic urticaria, and to compare these patients with healthy demographic control groups.

Methodology: Seventy six children and 38 adult patients with CSU were examined in terms of parasitic infections. The patients whom parasites were detected received anti-parasitic therapy and the improvements in CSU symptoms were evaluated. Stool samples were examined with direct microscopic examination (native-lugol), stool concentration and trichrome staining methods.

Results: In pediatric patient group, 18.4% (n = 14) of the stool samples were positive for Blastocystis sp., 2.6% (n = 2), Dientamoeba fragilis and 1.3% (n = 1), Giardia duodenalis. In adult patient group, Blastocystis sp. was detected in 18.4% (n = 7) of the stool samples. Anti-parasitic therapy yielded substantial improvement in urticaria symptoms in 57.1% of pediatric and 60.0% of adult patients.

Conclusions: Blastocystis sp. and D. fragilis may play a role in chronic urticaria which seriously disrupts the patient's quality of life. Parasitic infections should not be neglected in patients with cutaneous manifestations.

Published
2019-10-31
How to Cite
1.
Vezir S, Kaya F, Vezir E, Karaosmanoğlu N, Adiloğlu AK (2019) Evaluation of intestinal parasites in patients with chronic spontaneous urticaria in a territory hospital in Turkey. J Infect Dev Ctries 13:927-932. doi: 10.3855/jidc.11552
Section
Original Articles