Is genital tract infection related to tubal diseases in infertile Vietnamese women?

  • Minh Tam Le Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam https://orcid.org/0000-0001-6225-3108
  • Thi Le Na Nguyen Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam
  • Duong Dinh Le Department of Public Health, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam https://orcid.org/0000-0003-1607-0655
  • Tram Viet Quynh Ngo Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam
  • Anh Thi Chau Nguyen Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam
  • Bach Hoang Nguyen Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam
  • Huy Vu Quoc Nguyen Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam https://orcid.org/0000-0002-4744-7059
  • Thanh Ngoc Cao Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam https://orcid.org/0000-0001-6362-0934
  • Andres Salumets Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
  • Reet Mändar Competence Centre on Health Technologies, Tartu, Estonia
Keywords: genital tract infection, infertility, Vietnam, tubal diseases

Abstract

Introduction: The goal of this study was to identify the profile of genital tract infections and their relationship with clinical and demographic parameters as well as tubal diseases among infertile women in Vietnam.

Methodology: In this cross-sectional descriptive study, we enrolled 597 women undergoing infertility treatment at the Center for Reproductive Endocrinology & Infertility, Hue University Hospital, Vietnam. All of the study participants were interviewed and examined by a gynecologist. Consecutive tests were then conducted including direct microscopy examination (wet mount and Gram stain), vaginal culture, polymerase chain reaction (PCR) for chlamydia diagnosis from a cervical canal swab, and a blood test for syphilis detection. A hysterosalpingogram (HSG) was carried out to examine the uterine cavity and Fallopian tubes.

Results: A gynecologic infection was diagnosed in 43.4% (259/597) of the infertile women. Bacterial vaginosis was the most common condition at 19.6%of the cases. Candida spp., Chlamydia trachomatis, and Trichomonas vaginalis infections accounted for 17.4%, 3.7%, and 0.3%, respectively. Normal HSG results accounted for 87.4% of the women while 5.5% had 2-sided tubal occlusions, 5.4% had 1-sided tubal occlusions, 1.0% had 1-sided hydrosalpinx, and 0.7% had 2-sided hydrosalpinx. There was no significant association between tubal diseases and current infections; however, aerobic vaginitis increased the risk of tubal diseases by 2.4 times.

Conclusions: A marked proportion of infertile Vietnamese women have genital tract infections that can significantly influence their reproductive function and performance. These infections should be routinely screened and treated properly to prevent their consequences, such as infertility, which is especially important in developing countries.

Author Biographies

Minh Tam Le, Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam

Department of Obstetrics and Gynecology

Bach Hoang Nguyen, Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam

Department of Microbiology

Andres Salumets, Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia

Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Tartu, Tartu, 51014, Estonia

Competence Centre on Health Technologies AS, Tartu, 50410, Estonia

Institute of Bio- and Translational Medicine, University of Tartu, Tartu, 50411, Estonia

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland

Reet Mändar, Competence Centre on Health Technologies, Tartu, Estonia

Competence Centre on Health Technologies AS, Tartu, 50410, Estonia

Department of Microbiology, Institute of Biomedicine and Translational Medicine,  University of Tartu, Tartu, 50411, Estonia

Published
2019-10-31
How to Cite
1.
Le MT, Nguyen TLN, Le DD, Ngo TVQ, Nguyen ATC, Nguyen BH, Nguyen HVQ, Cao TN, Salumets A, Mändar R (2019) Is genital tract infection related to tubal diseases in infertile Vietnamese women?. J Infect Dev Ctries 13:906-913. doi: 10.3855/jidc.11632
Section
Original Articles