Usefulness of presepsin as diagnostic and prognostic marker of sepsis in daily clinical practice

  • Matjaz Jereb Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia
  • Matej Mavric Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia
  • Miha Skvarc Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
  • Alja Drobnic Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia
  • Spela Dolenc Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia
  • Natalija Planinc Strunjas Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia
  • Boris Luksic Department of Infectious Diseases, Clinical Hospital Center, Split, Croatia
  • Nina Grasselli Kmet Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia
Keywords: sepsis, inflammation markers, presepsin, diagnosis, prognosis

Abstract

Introduction: Sepsis represents a major cause of morbidity and mortality in critically ill patients. Early diagnosis and appropriate treatment have a crucial influence on survival. The aim of this study was to evaluate the diagnostic and prognostic role of presepsin (sCD14) in patients with sepsis.

Methodology: Fifty-four consecutive adult patients with sepsis and 26 patients with aseptic meningitis as a control group were included in this prospective observational study. In all patients included in the study, levels of C-reactive protein (CRP), presepsin, lactate, and a count of leukocytes and neutrophils were determined on admission. In those with suspected bacterial infection, two separate blood cultures were obtained and procalcitonin (PCT) concentration was detected. Plasma presepsin and PCT concentrations in septic group patients were followed on days 2, 3 and 7 after enrollment.

Results: The median presepsin serum concentration in patients with sepsis was 1614 pg/mL and in the control group it was 203 pg/mL (p < 0.001). Presepsin levels in patients with septic shock were higher than in sepsis patients (p < 0.014). The mean presepsin concentrations were higher in deceased than in surviving patients (p = 0.009). The trend of changes in presepsin concentrations in deceased patients was significantly different than in the surviving patients (p = 0.018). There were no statistically significant differences in the concentration of presepsin or other biomarkers in patients with Gram negative or Gram positive bacteria.

Conclusions: Presepsin may be used as a diagnostic marker of systemic bacterial infection and can predict the severity and outcome of sepsis.

Published
2019-11-30
How to Cite
1.
Jereb M, Mavric M, Skvarc M, Drobnic A, Dolenc S, Strunjas NP, Luksic B, Kmet NG (2019) Usefulness of presepsin as diagnostic and prognostic marker of sepsis in daily clinical practice. J Infect Dev Ctries 13:1038-1044. doi: 10.3855/jidc.11764
Section
Original Articles