Detection of Salmonella genes in stool samples of children aged 5 years and younger in urban and rural areas of Bangladesh

  • Shameem Akhter Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea
  • Jong-Hyeok Jung Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea
  • Bolormaa Munkhbileg Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea
  • Jae-Hyeon Jeong Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea
  • Jahirul Islam Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea
  • Mohammad Mushfequr Rahman Department of Microbiology, Bangladesh University of Health Sciences, Dhaka, Bangladesh
  • Shah Mohammad Zahurul Haque Asna Department of Microbiology, Bangladesh University of Health Sciences, Dhaka, Bangladesh
  • Hwa Jung Kim Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • Seung Hyeok Seok Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
  • Seung-Yong Seong Wide River Institute of Immunology, Seoul National University College of Medicine, Hongcheon, Republic of Korea
  • Sang-Uk Seo Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Keywords: Salmonella genes, Bangladesh, water-supply system, urban children, rural children, typhoid

Abstract

Introduction: Typhoid incidence in children is higher in urban areas than in rural areas of Bangladesh. This study examined whether healthy urban children harboured higher levels of Salmonella genes than healthy rural children.

Methodology: Stool samples from 140 children were studied: 70 from rural areas and 70 from urban metropolitan areas.

Results: The stool samples of urban children contained more Salmonella genes (median 4, IQR 3-4) than those of rural children (median 3, IQR 3-4). This suggests that urban Bangladeshi children have more Salmonella genes in their guts than rural children. Especially, in those under 12 months of age, the Salmonella gene prevalence in urban children was unique. They had more Salmonella genes (median 4, IQR 4-5) than rural children in the same age group (median 3, IQR 2.5-4). We also found more Salmonella genes in urban children who drank tap water (median 4, IQR 3-5) than in rural children whose water source was tube well water (median 3, IQR 2-4) and boiled pond water (median 3, IQR 3-3.5). However, there was no significant difference of Salmonella genes between urban children who drank tap-water and children whose water source was a tube well (median 4, IQR 3-4).

Conclusions: These data suggest that the urban environment, including the drinking water supply system, increases the likelihood of healthy children in urban areas harbouring more potentially pathogenic Salmonella organisms in their gut than found in rural healthy children.

Published
2021-04-30
How to Cite
1.
Akhter S, Jung J-H, Munkhbileg B, Jeong J-H, Islam J, Rahman MM, Asna SMZH, Kim HJ, Seok SH, Seong S-Y, Seo S-U (2021) Detection of Salmonella genes in stool samples of children aged 5 years and younger in urban and rural areas of Bangladesh. J Infect Dev Ctries 15:506-515. doi: 10.3855/jidc.12621
Section
Original Articles