Factors associated with increased odds of sensorineural hearing loss in infants exposed to the Zika virus during pregnancy

  • Erika J Verján-Carrillo Master of Medical Science Program, Faculty of Medicine, University of Colima, Colima, Mexico
  • Efrén Murillo-Zamora Department of Epidemiology, Family Medicine Unit No. 19, Mexican Institute of Social Security, Colima, Mexico
  • Gabriel Ceja-Espíritu Department of Epidemiology, Family Medicine Unit No. 19, Mexican Institute of Social Security, Colima, Mexico
  • José Guzmán-Esquivel Department of Epidemiology, Family Medicine Unit No. 19, Mexican Institute of Social Security, Colima, Mexico
  • Oliver Mendoza-Cano Faculty of Civil Engineering, University of Colima, Coquimatlan, Mexico
Keywords: Zika Virus, Pregnancy, Brain Stem, Hearing Loss, Sensorineural

Abstract

Introduction: The Zika virus (ZIKV) infection in pregnant women has been associated with an increased risk of birth defects. We aimed to estimate the prevalence of sensorineural hearing loss (SNHL) in infants exposed to the ZIKV during their gestation and evaluate the factors associated with its increased odds.

Methodology: A cross-sectional study was performed from July 2016 to June 2019 in a Western state of Mexico and data from 61 infants that presented with laboratory-positive (RT-qPCR) evidence of in utero exposure to ZIKV were analyzed. Brain stem auditory evoked potentials were used.

Results: Hearing loss was documented in 6 (9.8%) of infants. The prevalence of SNHL in children with microcephaly was 75.0%, as compared to 5.3% in those without anomalies (odds ratio, OR = 14.31, 95% CI = 2.54 – 19.12). Half of children with SNHL had no physical manifestations of gestational ZIKV exposure.

Conclusions: Hearing loss was a frequent event in ZIKV-exposed children, particularly among those with microcephaly. Our results highlight the relevance of systematic hearing screening.

Published
2021-04-30
How to Cite
1.
Verján-Carrillo EJ, Murillo-Zamora E, Ceja-Espíritu G, Guzmán-Esquivel J, Mendoza-Cano O (2021) Factors associated with increased odds of sensorineural hearing loss in infants exposed to the Zika virus during pregnancy. J Infect Dev Ctries 15:590-594. doi: 10.3855/jidc.12623
Section
Brief Original Articles