Conformity of yaws clinical features to combined rapid diagnostic test in children aged 2-15 years in an endemic area

Authors

  • Sri Linuwih SW Menaldi Department of Dermatology and Venereology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-3687-1871
  • Joanne Natasha Department of Dermatology and Venereology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-1069-0300
  • Joses Saputra Department of Dermatology and Venereology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-2625-1732
  • Melani Marissa Department of Dermatology and Venereology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-2194-5671
  • Yudo Irawan Department of Dermatology and Venereology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia
  • Dewi Friska Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia https://orcid.org/0000-0002-5994-7528
  • Danang Tri Wahyudi Department of Dermatology and Venereology, Dharmais Cancer Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-0502-6376

DOI:

https://doi.org/10.3855/jidc.16637

Keywords:

diagnosis, endemic, eradication, yaws

Abstract

Introduction: The diagnosis of yaws is established by clinical examination and confirmed through a laboratory test. Unrecognized lesions may lead to a missed opportunity for diagnosis and complete eradication of yaws. The use of Dual Path Platform (DPP® RDT) Syphilis Screen and Confirm RDT (Chembio, Medford, New York) has been recommended by the World Health Organization (WHO) for endemic areas with limited laboratory facilities. To date, there have not been any studies assessing the conformity of clinical features based on the WHO guidelines with DPP® RDT.

Methodology: A cross-sectional study was conducted to evaluate the conformity of yaws clinical features based on the WHO guidelines to the DPP® RDT. We recruited children aged 2–15 years old in Alor, Indonesia. All subjects underwent clinical examination and were tested with DPP® RDT. Fisher's exact test was used to analyze the overall agreement between the clinical features and the DPP® RDT results.

Results: A total of 197 study subjects (mean age 9 years) were enrolled. The most frequent skin lesion was a yaws scar (79.7%). Eight subjects (3%) were diagnosed with yaws based on the DPP® RDT examination. The overall agreement between clinical features and DPP® RDT was 26.9% (p = 0.202).

Conclusions: The conformity of clinical features in suspected yaws to DPP® RDT is low; thus, clinical features should not be used as a sole initial reference in establishing yaws diagnosis, even in endemic areas.

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Published

2022-12-31

How to Cite

1.
Menaldi SLS, Natasha J, Saputra J, Marissa M, Irawan Y, Friska D, Wahyudi DT (2022) Conformity of yaws clinical features to combined rapid diagnostic test in children aged 2-15 years in an endemic area. J Infect Dev Ctries 16:1914–1920. doi: 10.3855/jidc.16637

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Section

Original Articles